Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant Depression

Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant Depression

The potential of repetitive transcranial magnetic stimulation (rTMS) to treat numerous neurological and psychiatric disorders has been thoroughly studied for the last two decades. Here, we report for the first time, the case of a 65-year-old woman suffering from treatment-resistant depression who de...

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Main Authors: Guilhem Carle, Mehdi Touat, Nicolas Bruno, Damien Galanaud, Charles-Siegfried Peretti, Antoni Valero-Cabré, Richard Levy, Carole Azuar
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Psychiatry
Subjects:
depression
transcranial magnetic stimulation
frontal syndrome
antidepressant
state-dependency
executive dysfunction
Online Access:http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00096/full
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spelling doaj-9034d3db611c4908aa47889c83ea2c182020-11-24T20:56:50ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402017-05-01810.3389/fpsyt.2017.00096265316Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant DepressionGuilhem Carle0Guilhem Carle1Guilhem Carle2Mehdi Touat3Mehdi Touat4Nicolas Bruno5Nicolas Bruno6Damien Galanaud7Damien Galanaud8Charles-Siegfried Peretti9Charles-Siegfried Peretti10Antoni Valero-Cabré11Antoni Valero-Cabré12Antoni Valero-Cabré13Antoni Valero-Cabré14Richard Levy15Richard Levy16Richard Levy17Carole Azuar18Carole Azuar19Carole Azuar20AP-HP, Hôpital Saint-Antoine, Department of Psychiatry, Paris, FranceFrontLab, INSERM U1127, CNRS UMR7225, IHU Translational Neurosciences, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, FranceSorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, FranceAP-HP, Hôpital Saint-Antoine, Department of Neurology, Paris, FranceParis Sud University, Gustave Roussy, INSERM U981, Villejuif, FranceAP-HP, Hôpital Saint-Antoine, Department of Psychiatry, Paris, FranceSorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, FranceSorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, FranceAP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Neuroradiology, Paris, FranceAP-HP, Hôpital Saint-Antoine, Department of Psychiatry, Paris, FranceSorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, FranceFrontLab, INSERM U1127, CNRS UMR7225, IHU Translational Neurosciences, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, FranceSorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, FranceLaboratory for Cerebral Dynamics Plasticity and Rehabilitation, School of Medicine, Boston University, Boston, MA, USACognitive Neuroscience and Information Technology Research Program, Open University of Catalonia (UOC), Barcelona, SpainFrontLab, INSERM U1127, CNRS UMR7225, IHU Translational Neurosciences, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, FranceSorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, FranceAP-HP, Hôpital Saint-Antoine, Department of Neurology, Paris, FranceFrontLab, INSERM U1127, CNRS UMR7225, IHU Translational Neurosciences, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, FranceSorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, FranceAP-HP, Groupe Hospitalier Pitié-Salpêtrière, National Reference Centre on Rare Dementias, Paris, FranceThe potential of repetitive transcranial magnetic stimulation (rTMS) to treat numerous neurological and psychiatric disorders has been thoroughly studied for the last two decades. Here, we report for the first time, the case of a 65-year-old woman suffering from treatment-resistant depression who developed an acute frontal lobe syndrome following eight sessions of low-frequency rTMS (LF-rTMS) to the right dorsolateral prefrontal cortex while also treated with sertraline and mianserin. The pathophysiological mechanisms underlying such an unexpected acute frontal lobe dysfunction are discussed in relation to the therapeutic use of LF-rTMS in combination with pharmacotherapy in depressed patients.http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00096/fulldepressiontranscranial magnetic stimulationfrontal syndromeantidepressantstate-dependencyexecutive dysfunction
collection DOAJ
language English
format Article
sources DOAJ
author Guilhem Carle
Guilhem Carle
Guilhem Carle
Mehdi Touat
Mehdi Touat
Nicolas Bruno
Nicolas Bruno
Damien Galanaud
Damien Galanaud
Charles-Siegfried Peretti
Charles-Siegfried Peretti
Antoni Valero-Cabré
Antoni Valero-Cabré
Antoni Valero-Cabré
Antoni Valero-Cabré
Richard Levy
Richard Levy
Richard Levy
Carole Azuar
Carole Azuar
Carole Azuar
spellingShingle Guilhem Carle
Guilhem Carle
Guilhem Carle
Mehdi Touat
Mehdi Touat
Nicolas Bruno
Nicolas Bruno
Damien Galanaud
Damien Galanaud
Charles-Siegfried Peretti
Charles-Siegfried Peretti
Antoni Valero-Cabré
Antoni Valero-Cabré
Antoni Valero-Cabré
Antoni Valero-Cabré
Richard Levy
Richard Levy
Richard Levy
Carole Azuar
Carole Azuar
Carole Azuar
Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant Depression
Frontiers in Psychiatry
depression
transcranial magnetic stimulation
frontal syndrome
antidepressant
state-dependency
executive dysfunction
author_facet Guilhem Carle
Guilhem Carle
Guilhem Carle
Mehdi Touat
Mehdi Touat
Nicolas Bruno
Nicolas Bruno
Damien Galanaud
Damien Galanaud
Charles-Siegfried Peretti
Charles-Siegfried Peretti
Antoni Valero-Cabré
Antoni Valero-Cabré
Antoni Valero-Cabré
Antoni Valero-Cabré
Richard Levy
Richard Levy
Richard Levy
Carole Azuar
Carole Azuar
Carole Azuar
author_sort Guilhem Carle
title Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant Depression
title_short Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant Depression
title_full Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant Depression
title_fullStr Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant Depression
title_full_unstemmed Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant Depression
title_sort acute frontal lobe dysfunction following prefrontal low-frequency repetitive transcranial magnetic stimulation in a patient with treatment-resistant depression
publisher Frontiers Media S.A.
series Frontiers in Psychiatry
issn 1664-0640
publishDate 2017-05-01
description The potential of repetitive transcranial magnetic stimulation (rTMS) to treat numerous neurological and psychiatric disorders has been thoroughly studied for the last two decades. Here, we report for the first time, the case of a 65-year-old woman suffering from treatment-resistant depression who developed an acute frontal lobe syndrome following eight sessions of low-frequency rTMS (LF-rTMS) to the right dorsolateral prefrontal cortex while also treated with sertraline and mianserin. The pathophysiological mechanisms underlying such an unexpected acute frontal lobe dysfunction are discussed in relation to the therapeutic use of LF-rTMS in combination with pharmacotherapy in depressed patients.
topic depression
transcranial magnetic stimulation
frontal syndrome
antidepressant
state-dependency
executive dysfunction
url http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00096/full
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