Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes

Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes

The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic...

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Bibliographic Details
Main Authors: Rogerio R. Sotelo-Mundo, Enrique F. Velázquez-Contreras, Gustavo A. González-Aguilar, Enrique Rudiño-Piñera, Jesús Hernández, Eli Teran-Cabanillas, Rocío Sugich-Miranda, Alex J. Salazar-Medina
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Molecules
Subjects:
cyclophane
macrocycle
iron
biomimetic
antioxidant
Online Access:http://www.mdpi.com/1420-3049/18/2/1762
Description
Summary:The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.
ISSN:1420-3049

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