Curcumin and Heme Oxygenase: Neuroprotection and Beyond

Curcumin is a natural polyphenol component of <i>Curcuma longa Linn</i>, which is currently considered one of the most effective nutritional antioxidants for counteracting free radical-related diseases. Several experimental data have highlighted the pleiotropic neuroprotective effects of...

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Main Authors:	Emanuela Mhillaj, Andrea Tarozzi, Letizia Pruccoli, Vincenzo Cuomo, Luigia Trabace, Cesare Mancuso
Format:	Article
Language:	English
Published:	MDPI AG 2019-05-01
Series:	International Journal of Molecular Sciences
Subjects:	curcumin free radicals heme oxygenase neuroprotection safety profile
Online Access:	https://www.mdpi.com/1422-0067/20/10/2419

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record_format	Article
spelling	doaj-9039a17a914d44ff886d98c140ed72b12020-11-25T01:04:32ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-05-012010241910.3390/ijms20102419ijms20102419Curcumin and Heme Oxygenase: Neuroprotection and BeyondEmanuela Mhillaj0Andrea Tarozzi1Letizia Pruccoli2Vincenzo Cuomo3Luigia Trabace4Cesare Mancuso5Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDepartment for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47900 Rimini, ItalyDepartment for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47900 Rimini, ItalyDepartment of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyFondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCurcumin is a natural polyphenol component of <i>Curcuma longa Linn</i>, which is currently considered one of the most effective nutritional antioxidants for counteracting free radical-related diseases. Several experimental data have highlighted the pleiotropic neuroprotective effects of curcumin, due to its activity in multiple antioxidant and anti-inflammatory pathways involved in neurodegeneration. Although its poor systemic bioavailability after oral administration and low plasma concentrations represent restrictive factors for curcumin therapeutic efficacy, innovative delivery formulations have been developed in order to overwhelm these limitations. This review provides a summary of the main findings involving the heme oxygenase/biliverdin reductase system as a valid target in mediating the potential neuroprotective properties of curcumin. Furthermore, pharmacokinetic properties and concerns about curcumin’s safety profile have been addressed.https://www.mdpi.com/1422-0067/20/10/2419curcuminfree radicalsheme oxygenaseneuroprotectionsafety profile
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Emanuela Mhillaj Andrea Tarozzi Letizia Pruccoli Vincenzo Cuomo Luigia Trabace Cesare Mancuso
spellingShingle	Emanuela Mhillaj Andrea Tarozzi Letizia Pruccoli Vincenzo Cuomo Luigia Trabace Cesare Mancuso Curcumin and Heme Oxygenase: Neuroprotection and Beyond International Journal of Molecular Sciences curcumin free radicals heme oxygenase neuroprotection safety profile
author_facet	Emanuela Mhillaj Andrea Tarozzi Letizia Pruccoli Vincenzo Cuomo Luigia Trabace Cesare Mancuso
author_sort	Emanuela Mhillaj
title	Curcumin and Heme Oxygenase: Neuroprotection and Beyond
title_short	Curcumin and Heme Oxygenase: Neuroprotection and Beyond
title_full	Curcumin and Heme Oxygenase: Neuroprotection and Beyond
title_fullStr	Curcumin and Heme Oxygenase: Neuroprotection and Beyond
title_full_unstemmed	Curcumin and Heme Oxygenase: Neuroprotection and Beyond
title_sort	curcumin and heme oxygenase: neuroprotection and beyond
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2019-05-01
description	Curcumin is a natural polyphenol component of <i>Curcuma longa Linn</i>, which is currently considered one of the most effective nutritional antioxidants for counteracting free radical-related diseases. Several experimental data have highlighted the pleiotropic neuroprotective effects of curcumin, due to its activity in multiple antioxidant and anti-inflammatory pathways involved in neurodegeneration. Although its poor systemic bioavailability after oral administration and low plasma concentrations represent restrictive factors for curcumin therapeutic efficacy, innovative delivery formulations have been developed in order to overwhelm these limitations. This review provides a summary of the main findings involving the heme oxygenase/biliverdin reductase system as a valid target in mediating the potential neuroprotective properties of curcumin. Furthermore, pharmacokinetic properties and concerns about curcumin’s safety profile have been addressed.
topic	curcumin free radicals heme oxygenase neuroprotection safety profile
url	https://www.mdpi.com/1422-0067/20/10/2419
work_keys_str_mv	AT emanuelamhillaj curcuminandhemeoxygenaseneuroprotectionandbeyond AT andreatarozzi curcuminandhemeoxygenaseneuroprotectionandbeyond AT letiziapruccoli curcuminandhemeoxygenaseneuroprotectionandbeyond AT vincenzocuomo curcuminandhemeoxygenaseneuroprotectionandbeyond AT luigiatrabace curcuminandhemeoxygenaseneuroprotectionandbeyond AT cesaremancuso curcuminandhemeoxygenaseneuroprotectionandbeyond
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Curcumin and Heme Oxygenase: Neuroprotection and Beyond

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