Complex Hydrogels Composed of Chitosan with Ring-opened Polyvinyl Pyrrolidone as a Gastroretentive Drug Dosage Form to Enhance the Bioavailability of Bisphosphonates
Abstract Complex hydrogels formed with chitosan (CS) and ring-opened polyvinyl pyrrolidone (roPVP) as a swellable mucoadhesive gastroretentive drug dosage form (smGRDDF) were prepared and characterized. CS/roPVP hydrogels were produced by blending CS with roPVP obtained by basic treatment of PVP. Ef...
Main Authors: | Chia-Yu Su, Hsiu-O Ho, Ying-Chen Chen, Yu-Ting Yu, Der-Zen Liu, Fang-Ching Chao, Ming-Thau Sheu |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-05-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-018-26432-2 |
Similar Items
-
Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate
by: Chen YC, et al.
Published: (2013-12-01) -
Chitosan–Polyvinyl Pyrrolidone Hydrogels as Candidate for Islet Immunoisolation: In Vitro Biocompatibility Evaluation
by: Makarand Risbud, et al.
Published: (2000-01-01) -
Chitosan-Polyvinyl Pyrrolidone Hydrogel does Not Activate Macrophages: Potentials for Transplantation Applications
by: Makarand Risbud, et al.
Published: (2001-03-01) -
Silk Fibroin/Polyvinyl Pyrrolidone Interpenetrating Polymer Network Hydrogels
by: Dajiang Kuang, et al.
Published: (2018-02-01) -
The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats
by: Reza Fazeli-Varzaneh, et al.
Published: (2015-02-01)