Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma

Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma

Abstract Background Retinoblastoma (Rb) is the most common primary intraocular tumor in children. Local treatment of the intraocular disease is usually effective if diagnosed early; however advanced Rb can metastasize through routes that involve invasion of the choroid, sclera and optic nerve or mor...

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Main Authors: Anderson H. Webb, Bradley T. Gao, Zachary K. Goldsmith, Andrew S. Irvine, Nabil Saleh, Ryan P. Lee, Justin B. Lendermon, Rajini Bheemreddy, Qiuhua Zhang, Rachel C. Brennan, Dianna Johnson, Jena J. Steinle, Matthew W. Wilson, Vanessa M. Morales-Tirado
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Cancer
Subjects:
Matrix metalloproteinases
MMP-2
MMP-9
Retinoblastoma
Therapy
Metastasis
Online Access:http://link.springer.com/article/10.1186/s12885-017-3418-y

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