Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios.
Based on epidemiologic and embryologic patterns, nonsyndromic orofacial clefts- the most common craniofacial birth defects in humans- are commonly categorized into cleft lip with or without cleft palate (CL/P) and cleft palate alone (CP), which are traditionally considered to be etiologically distin...
Main Authors: | Debashree Ray, Sowmya Venkataraghavan, Wanying Zhang, Elizabeth J Leslie, Jacqueline B Hetmanski, Seth M Weinberg, Jeffrey C Murray, Mary L Marazita, Ingo Ruczinski, Margaret A Taub, Terri H Beaty |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-07-01
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Series: | PLoS Genetics |
Online Access: | https://doi.org/10.1371/journal.pgen.1009584 |
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