Bioactive polymeric scaffolds for tissue engineering
A variety of engineered scaffolds have been created for tissue engineering using polymers, ceramics and their composites. Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue reg...
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KeAi Communications Co., Ltd.
2016-12-01
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doaj-905e01b0207d4036a0f89c4f368f23f12021-03-02T11:11:50ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2016-12-01129310810.1016/j.bioactmat.2016.11.001Bioactive polymeric scaffolds for tissue engineeringScott Stratton0Namdev B. Shelke1Kazunori Hoshino2Swetha Rudraiah3Sangamesh G. Kumbar4Department of Orthopaedic Surgery, UConn Health, Farmington, CT, USADepartment of Orthopaedic Surgery, UConn Health, Farmington, CT, USADepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USADepartment of Pharmaceutical Sciences, School of Pharmacy, University of Saint Joseph, Hartford, CT, 06103, USADepartment of Orthopaedic Surgery, UConn Health, Farmington, CT, USAA variety of engineered scaffolds have been created for tissue engineering using polymers, ceramics and their composites. Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue regeneration. Scaffolds fabricated via salt leaching, particle sintering, hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo. Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity. Traditional scaffold fabrication techniques often failed to create intricate structures with greater resolution, not reproducible and involved multiple steps. The 3D printing technology overcome several limitations of the traditional techniques and made it easier to adopt several thermoplastics and hydrogels to create micro-nanostructured scaffolds and devices for tissue engineering and drug delivery. This review highlights scaffold fabrication methodologies with a focus on optimizing scaffold performance through the matrix pores, bioactivity and degradation rate to enable tissue regeneration. Review highlights few examples of bioactive scaffold mediated nerve, muscle, tendon/ligament and bone regeneration. Regardless of the efforts required for optimization, a shift in 3D scaffold uses from the laboratory into everyday life is expected in the near future as some of the methods discussed in this review become more streamlined.http://www.sciencedirect.com/science/article/pii/S2452199X16300238BioactiveBiomaterialsScaffoldPorosityBiodegradableTissue regeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Scott Stratton Namdev B. Shelke Kazunori Hoshino Swetha Rudraiah Sangamesh G. Kumbar |
spellingShingle |
Scott Stratton Namdev B. Shelke Kazunori Hoshino Swetha Rudraiah Sangamesh G. Kumbar Bioactive polymeric scaffolds for tissue engineering Bioactive Materials Bioactive Biomaterials Scaffold Porosity Biodegradable Tissue regeneration |
author_facet |
Scott Stratton Namdev B. Shelke Kazunori Hoshino Swetha Rudraiah Sangamesh G. Kumbar |
author_sort |
Scott Stratton |
title |
Bioactive polymeric scaffolds for tissue engineering |
title_short |
Bioactive polymeric scaffolds for tissue engineering |
title_full |
Bioactive polymeric scaffolds for tissue engineering |
title_fullStr |
Bioactive polymeric scaffolds for tissue engineering |
title_full_unstemmed |
Bioactive polymeric scaffolds for tissue engineering |
title_sort |
bioactive polymeric scaffolds for tissue engineering |
publisher |
KeAi Communications Co., Ltd. |
series |
Bioactive Materials |
issn |
2452-199X |
publishDate |
2016-12-01 |
description |
A variety of engineered scaffolds have been created for tissue engineering using polymers, ceramics and their composites. Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue regeneration. Scaffolds fabricated via salt leaching, particle sintering, hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo. Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity. Traditional scaffold fabrication techniques often failed to create intricate structures with greater resolution, not reproducible and involved multiple steps. The 3D printing technology overcome several limitations of the traditional techniques and made it easier to adopt several thermoplastics and hydrogels to create micro-nanostructured scaffolds and devices for tissue engineering and drug delivery. This review highlights scaffold fabrication methodologies with a focus on optimizing scaffold performance through the matrix pores, bioactivity and degradation rate to enable tissue regeneration. Review highlights few examples of bioactive scaffold mediated nerve, muscle, tendon/ligament and bone regeneration. Regardless of the efforts required for optimization, a shift in 3D scaffold uses from the laboratory into everyday life is expected in the near future as some of the methods discussed in this review become more streamlined. |
topic |
Bioactive Biomaterials Scaffold Porosity Biodegradable Tissue regeneration |
url |
http://www.sciencedirect.com/science/article/pii/S2452199X16300238 |
work_keys_str_mv |
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