Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum
In this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug de...
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doaj-907814b737284a4fa3b5a14312ec6f702020-11-24T23:02:46ZengMDPI AGMolecules1420-30492016-09-012110130610.3390/molecules21101306molecules21101306Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseumCarlo Romagnoli0Anna Baldisserotto1Chiara B. Vicentini2Donatella Mares3Elisa Andreotti4Silvia Vertuani5Stefano Manfredini6Department of Life Sciences, University of Modena and Reggio Emilia, Viale Caduti in Guerra 127, 41121 Modena, ItalyDepartment of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, ItalyDepartment of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, ItalyDepartment of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, Viale Caduti in Guerra 127, 41121 Modena, ItalyDepartment of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, ItalyDepartment of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, ItalyIn this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. The antidermatophytic activities of the three skin lighteners were evaluated relative to the known antifungal drug fluconazole on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Arthroderma cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Nannizzia gypsea, Trichophyton rubrum and Trichophyton tonsurans. Among the three tested resorcinols, only two showed promising properties, with the ability to inhibit the growth of all tested dermatophytes; additionally, the IC50 values of these two resorcinols against the nine dermatophytes confirmed their good antifungal activity, particularly for phenylethyl resorcinol against M. gypseum. Ultrastructural alterations exhibited by the fungus were observed using scanning electron microscopy and transmission electron microscopy and reflected a dose-dependent response to treatment with the activation of defence and self-preservation strategies.http://www.mdpi.com/1420-3049/21/10/1306resorcinol derivativesdermatophytesMicrosporum gypseumantifungal activityTEMSEM |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carlo Romagnoli Anna Baldisserotto Chiara B. Vicentini Donatella Mares Elisa Andreotti Silvia Vertuani Stefano Manfredini |
spellingShingle |
Carlo Romagnoli Anna Baldisserotto Chiara B. Vicentini Donatella Mares Elisa Andreotti Silvia Vertuani Stefano Manfredini Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum Molecules resorcinol derivatives dermatophytes Microsporum gypseum antifungal activity TEM SEM |
author_facet |
Carlo Romagnoli Anna Baldisserotto Chiara B. Vicentini Donatella Mares Elisa Andreotti Silvia Vertuani Stefano Manfredini |
author_sort |
Carlo Romagnoli |
title |
Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum |
title_short |
Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum |
title_full |
Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum |
title_fullStr |
Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum |
title_full_unstemmed |
Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum |
title_sort |
antidermatophytic action of resorcinol derivatives: ultrastructural evidence of the activity of phenylethyl resorcinol against microsporum gypseum |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2016-09-01 |
description |
In this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. The antidermatophytic activities of the three skin lighteners were evaluated relative to the known antifungal drug fluconazole on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Arthroderma cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Nannizzia gypsea, Trichophyton rubrum and Trichophyton tonsurans. Among the three tested resorcinols, only two showed promising properties, with the ability to inhibit the growth of all tested dermatophytes; additionally, the IC50 values of these two resorcinols against the nine dermatophytes confirmed their good antifungal activity, particularly for phenylethyl resorcinol against M. gypseum. Ultrastructural alterations exhibited by the fungus were observed using scanning electron microscopy and transmission electron microscopy and reflected a dose-dependent response to treatment with the activation of defence and self-preservation strategies. |
topic |
resorcinol derivatives dermatophytes Microsporum gypseum antifungal activity TEM SEM |
url |
http://www.mdpi.com/1420-3049/21/10/1306 |
work_keys_str_mv |
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1725635308910804992 |