Prevalence and Phenotypic Expression of Mutations in the MYH7, MYBPC3 and TNNT2 Genes in Families with Hypertrophic Cardiomyopathy in the South of Brazil: A Cross-Sectional Study

Prevalence and Phenotypic Expression of Mutations in the MYH7, MYBPC3 and TNNT2 Genes in Families with Hypertrophic Cardiomyopathy in the South of Brazil: A Cross-Sectional Study

Abstract Background: Mutations in sarcomeric genes are found in 60-70% of individuals with familial forms of hypertrophic cardiomyopathy (HCM). However, this estimate refers to northern hemisphere populations. The molecular-genetic profile of HCM has been subject of few investigations in Brazil, pa...

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Bibliographic Details
Main Authors: Beatriz Piva e Mattos, Fernando Luís Scolari, Marco Antonio Rodrigues Torres, Laura Simon, Valéria Centeno de Freitas, Roberto Giugliani, Úrsula Matte
Format: Article
Language:English
Published: Sociedade Brasileira de Cardiologia (SBC)
Series:Arquivos Brasileiros de Cardiologia
Subjects:
Mutation / genetics
Cardiomyopathy, Hypertrophic
Epidemiology
Sarcomeres
Ethnicity and Health
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004200257&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004200257&lng=en&tlng=en

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