An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?

An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?

Amyloid-β (Aβ) 1-40 and 1-42 peptides are key mediators of synaptic and cognitive dysfunction in Alzheimer’s disease (AD). Whereas in AD, Aβ is found to act as a pro-epileptogenic factor even before plaque formation, amyloid pathology has been detected among patients with epilepsy with increased ris...

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Bibliographic Details
Main Authors: Miriam Sciaccaluga, Alfredo Megaro, Giovanni Bellomo, Gabriele Ruffolo, Michele Romoli, Eleonora Palma, Cinzia Costa
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
Aβ oligomers
hyperexcitability
excitatory/inhibitory unbalance
synaptic plasticity
network dysfunction
neurotoxicity
Online Access:https://www.mdpi.com/1422-0067/22/11/5991

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https://www.mdpi.com/1422-0067/22/11/5991

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