An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?
Amyloid-β (Aβ) 1-40 and 1-42 peptides are key mediators of synaptic and cognitive dysfunction in Alzheimer’s disease (AD). Whereas in AD, Aβ is found to act as a pro-epileptogenic factor even before plaque formation, amyloid pathology has been detected among patients with epilepsy with increased ris...
Main Authors: | Miriam Sciaccaluga, Alfredo Megaro, Giovanni Bellomo, Gabriele Ruffolo, Michele Romoli, Eleonora Palma, Cinzia Costa |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-06-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/11/5991 |
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