Efficacy and safety of different nonsteroidal anti-inflammatory drugs for acute neck and back pain

• Main Authors: E. Yu. Plotnikova, V. N. Zolotukhina, L. K. Isakov, M. N. Sinkova, M. A. Sinkov
• Format: Article
• Language: Russian
• Published: IMA-PRESS LLC 2020-04-01
• Series: Nevrologiâ, Nejropsihiatriâ, Psihosomatika
• Subjects: acute neck and back pain; acute dorsalgia; ketoprofen; aceclofenac; naproxen; dexketoprofen; nonsteroidal anti-inflammatory drugs
• Online Access: https://nnp.ima-press.net/nnp/article/view/1303

Objective: to comparatively study several nonsteroidal anti-inflammatory drugs (NSAIDs) (their analgesic effect; dynamics of quality of life; side effects, such as NSAID-gastropathy and gastric dyspepsia) in acute pain in the neck and back (dorsalgia).Patients and methods. The investigators followed up 120 patients (4 groups, each having 30 people) with acute dorsalgia who took different oral NSAIDs for 7 days: long-acting ketoprofen, aceclofenac, naproxen, and dexketoprofen (Flamadex). To evaluate their possible side effects, dyspepsia symptoms were monitored and blood pressure (BP) was measured daily; gastroscopy was repeated after completion of a treatment cycle. The Nottingham Quality of Life Questionnaire and the Visual Analogue Scale (VAS) for pain were used.Results and discussion. A gradual and substantial reduction in pain measured according to VAS was noted in all the NSAID-treated groups. The intensity of pain syndrome decreased faster in the dexketoprofen group; the analgesic effect of naproxen and long-acting aceclofenac was significantly less (p=0.012 and 0.002, respectively). This patient group showed a tendency to maximum improvement according to the Nottingham Quality of Life Questionnaire and VAS. Elevated BP was observed in all the groups, but statistically significantly more frequently in the naproxen group (p=0.05). Gastric dyspepsia was also registered in all the groups, but a tendency to its lower frequency was seen in thedexketoprofen group. Conclusion. Dexketoprofen showed fewer side effects and a more pronounced analgesic effect than ketoprofen, aceclofenac, and naproxen in acute dorsalgia.