In-situ vaccination using focused ultrasound heating and anti-CD-40 agonistic antibody enhances T-cell mediated local and abscopal effects in murine melanoma

In-situ vaccination using focused ultrasound heating and anti-CD-40 agonistic antibody enhances T-cell mediated local and abscopal effects in murine melanoma

The success of melanoma immunotherapy is dependent on the presence of activated and functional T-cells in tumors. The objective of this study was to investigate the impact of local-focused ultrasound (FUS) heating (∼42–45 °C) and in-situ anti-CD-40 agonistic antibody in enhancing T-cell function for...

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Bibliographic Details
Main Authors: Mohit Pratap Singh, Sri Nandhini Sethuraman, Jerry Ritchey, Steven Fiering, Chandan Guha, Jerry Malayer, Ashish Ranjan
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:International Journal of Hyperthermia
Subjects:
t-cell exhaustion
focused ultrasound
cd-40
melanoma
m1 macrophages
Online Access:http://dx.doi.org/10.1080/02656736.2019.1663280

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