Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction
In Wnt/β-catenin signaling, the transcriptional coactivator β-catenin is regulated by its phosphorylation in a complex that includes the scaffold protein Axin and associated kinases. Wnt binding to its coreceptors activates the cytosolic effector Dishevelled (Dvl), leading to the recruitment of Axin...
Main Authors: | Wei Kan, Michael D Enos, Elgin Korkmazhan, Stefan Muennich, Dong-Hua Chen, Melissa V Gammons, Mansi Vasishtha, Mariann Bienz, Alexander R Dunn, Georgios Skiniotis, William I Weis |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/55015 |
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