Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation
The data described in this article are related to “High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans” (Manfrini et al., in press) [1]. eIF6 is a translation initi...
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doaj-90a2711261e04c62b6f9129bf6d6a1b52020-11-25T01:44:09ZengElsevierData in Brief2352-34092017-10-0114C65365810.1016/j.dib.2017.08.023Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturationNicola Manfrini0Sara Ricciardi1Annarita Miluzio2Maya Fedeli3Alessandra Scagliola4Simone Gallo5Thure Adler6Dirk H. Busch7Valerie Gailus-Durner8Helmut Fuchs9Martin Hrabě de Angelis10Stefano Biffo11National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, ItalyNational Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, ItalyNational Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, ItalyExperimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, DIBIT, H. San Raffaele Scientific Institute, via Olgettina 58, 20132 Milan, ItalyNational Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, ItalyNational Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, ItalyGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, GermanyInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Trogerstrasse 30, 81675 Munich, GermanyGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, GermanyGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, GermanyGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, GermanyNational Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, ItalyThe data described in this article are related to “High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans” (Manfrini et al., in press) [1]. eIF6 is a translation initiation factor required for ribosomal biogenesis (Sanvito et al., 1999) [2] and for proper translational initiation (Gallo and Manfrini, 2015; Miluzio et al., 2016) [3,4] whose protein abundance requires tight regulation. Here we analyze by flow cytometry the effects of eIF6 depletion on proportions of specific innate and adaptive immune system subpopulations and on thymocyte maturation in mice.http://www.sciencedirect.com/science/article/pii/S2352340917304006eIF6Immune systemInnate immunityAdaptive immunityThymocyte |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicola Manfrini Sara Ricciardi Annarita Miluzio Maya Fedeli Alessandra Scagliola Simone Gallo Thure Adler Dirk H. Busch Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Stefano Biffo |
spellingShingle |
Nicola Manfrini Sara Ricciardi Annarita Miluzio Maya Fedeli Alessandra Scagliola Simone Gallo Thure Adler Dirk H. Busch Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Stefano Biffo Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation Data in Brief eIF6 Immune system Innate immunity Adaptive immunity Thymocyte |
author_facet |
Nicola Manfrini Sara Ricciardi Annarita Miluzio Maya Fedeli Alessandra Scagliola Simone Gallo Thure Adler Dirk H. Busch Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Stefano Biffo |
author_sort |
Nicola Manfrini |
title |
Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation |
title_short |
Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation |
title_full |
Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation |
title_fullStr |
Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation |
title_full_unstemmed |
Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation |
title_sort |
data on the effects of eif6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation |
publisher |
Elsevier |
series |
Data in Brief |
issn |
2352-3409 |
publishDate |
2017-10-01 |
description |
The data described in this article are related to “High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans” (Manfrini et al., in press) [1]. eIF6 is a translation initiation factor required for ribosomal biogenesis (Sanvito et al., 1999) [2] and for proper translational initiation (Gallo and Manfrini, 2015; Miluzio et al., 2016) [3,4] whose protein abundance requires tight regulation. Here we analyze by flow cytometry the effects of eIF6 depletion on proportions of specific innate and adaptive immune system subpopulations and on thymocyte maturation in mice. |
topic |
eIF6 Immune system Innate immunity Adaptive immunity Thymocyte |
url |
http://www.sciencedirect.com/science/article/pii/S2352340917304006 |
work_keys_str_mv |
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