The gut microbiome influences the bioavailability of olanzapine in rats

The gut microbiome influences the bioavailability of olanzapine in rats

Background: The role of the gut microbiome in the biotransformation of drugs has recently come under scrutiny. It remains unclear whether the gut microbiome directly influences the extent of drug absorbed after oral administration and thus potentially alters clinical pharmacokinetics. Methods: In th...

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Bibliographic Details
Main Authors: Sofia Cussotto, Jacinta Walsh, Anna V. Golubeva, Alexander V. Zhdanov, Conall R. Strain, Fiona Fouhy, Catherine Stanton, Timothy G. Dinan, Niall P. Hyland, Gerard Clarke, John F. Cryan, Brendan T. Griffin
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:EBioMedicine
Subjects:
Antipsychotic
Microbiome
Pharmacokinetics
Diversity
Bioavailability
CYP
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421001006

Internet

http://www.sciencedirect.com/science/article/pii/S2352396421001006

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