Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system
<p>Abstract</p> <p>Particle size is a key feature in determining performance of nanoparticles as drug carriers because it influences circulating half-life, cellular uptake and biodistribution. Because the size of particles has such a major impact on their performance, the uniformit...
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doaj-90a8c63244d44528a082fb87d49d883a2020-11-24T23:39:17ZengBMCJournal of Nanobiotechnology1477-31552010-08-01811810.1186/1477-3155-8-18Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation systemXie HuiSmith Jeffrey W<p>Abstract</p> <p>Particle size is a key feature in determining performance of nanoparticles as drug carriers because it influences circulating half-life, cellular uptake and biodistribution. Because the size of particles has such a major impact on their performance, the uniformity of the particle population is also a significant factor. Particles comprised of the polymer poly(lactic-co-glycolic acid) (PLGA) are widely studied as therapeutic delivery vehicles because they are biodegradable and biocompatible. In fact, microparticles comprised of PLGA are already approved for drug delivery. Unfortunately, PLGA nanoparticles prepared by conventional methods usually lack uniformity. We developed a novel Fluidic NanoPrecipitation System (FNPS) to fabricate highly uniform PLGA particles. Several parameters can be fine-tuned to generate particles of various sizes.</p> http://www.jnanobiotechnology.com/content/8/1/18 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xie Hui Smith Jeffrey W |
spellingShingle |
Xie Hui Smith Jeffrey W Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system Journal of Nanobiotechnology |
author_facet |
Xie Hui Smith Jeffrey W |
author_sort |
Xie Hui |
title |
Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system |
title_short |
Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system |
title_full |
Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system |
title_fullStr |
Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system |
title_full_unstemmed |
Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system |
title_sort |
fabrication of plga nanoparticles with a fluidic nanoprecipitation system |
publisher |
BMC |
series |
Journal of Nanobiotechnology |
issn |
1477-3155 |
publishDate |
2010-08-01 |
description |
<p>Abstract</p> <p>Particle size is a key feature in determining performance of nanoparticles as drug carriers because it influences circulating half-life, cellular uptake and biodistribution. Because the size of particles has such a major impact on their performance, the uniformity of the particle population is also a significant factor. Particles comprised of the polymer poly(lactic-co-glycolic acid) (PLGA) are widely studied as therapeutic delivery vehicles because they are biodegradable and biocompatible. In fact, microparticles comprised of PLGA are already approved for drug delivery. Unfortunately, PLGA nanoparticles prepared by conventional methods usually lack uniformity. We developed a novel Fluidic NanoPrecipitation System (FNPS) to fabricate highly uniform PLGA particles. Several parameters can be fine-tuned to generate particles of various sizes.</p> |
url |
http://www.jnanobiotechnology.com/content/8/1/18 |
work_keys_str_mv |
AT xiehui fabricationofplgananoparticleswithafluidicnanoprecipitationsystem AT smithjeffreyw fabricationofplgananoparticleswithafluidicnanoprecipitationsystem |
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