Lysosomal Cathepsin A Plays Significant Role In The Processing Of Endogenous Bioactive Peptides
Lysosomal serine carboxypeptidase Cathepsin A (CTSA) is a multifunctional enzyme with distinct protective and catalytic function. CTSA that is present in the lysosomal multienzyme complex facilitates correct lysosomal routing, stability and activation of betagalactosidase and alpha-neuraminidase. I...
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doaj-90b4e83fadd04f7ab8c1867cbe4ee31b2020-11-24T20:49:06ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2016-10-01310.3389/fmolb.2016.00068222625Lysosomal Cathepsin A Plays Significant Role In The Processing Of Endogenous Bioactive PeptidesZehra Timur0Secil Akyildiz1Volkan Seyrantepe2Izmir Institute of TechnologyIzmir Institute of TechnologyIzmir Institute of TechnologyLysosomal serine carboxypeptidase Cathepsin A (CTSA) is a multifunctional enzyme with distinct protective and catalytic function. CTSA that is present in the lysosomal multienzyme complex facilitates correct lysosomal routing, stability and activation of betagalactosidase and alpha-neuraminidase. In addition, CTSA plays a role in the inactivation of bioactive peptides including bradykinin, substances P, oxytocin, angiotensin I and endothelin-I by cleavage of one or two amino acid(s) from the C-terminal ends. In this study, we aimed to elucidate the regulatory role of CTSA on bioactive peptides in a knock-in mouse model of CTSAS190A. We evaluated the levels of bradykinin, substances P, oxytocin, angiotensin I and endothelin-I in the kidney, liver, lung, brain and serum of the CTSAS190A mouse model at three- and six-months of age. Our results suggest that CTSA selectively contributes to the processing of bioactive peptides in different tissues of CTSAS190A mice compared to those of age-matched wild-type mice.http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00068/fullCathepsin AMouseregulationLysosomebioactive peptid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zehra Timur Secil Akyildiz Volkan Seyrantepe |
spellingShingle |
Zehra Timur Secil Akyildiz Volkan Seyrantepe Lysosomal Cathepsin A Plays Significant Role In The Processing Of Endogenous Bioactive Peptides Frontiers in Molecular Biosciences Cathepsin A Mouse regulation Lysosome bioactive peptid |
author_facet |
Zehra Timur Secil Akyildiz Volkan Seyrantepe |
author_sort |
Zehra Timur |
title |
Lysosomal Cathepsin A Plays Significant Role In The Processing Of Endogenous Bioactive Peptides |
title_short |
Lysosomal Cathepsin A Plays Significant Role In The Processing Of Endogenous Bioactive Peptides |
title_full |
Lysosomal Cathepsin A Plays Significant Role In The Processing Of Endogenous Bioactive Peptides |
title_fullStr |
Lysosomal Cathepsin A Plays Significant Role In The Processing Of Endogenous Bioactive Peptides |
title_full_unstemmed |
Lysosomal Cathepsin A Plays Significant Role In The Processing Of Endogenous Bioactive Peptides |
title_sort |
lysosomal cathepsin a plays significant role in the processing of endogenous bioactive peptides |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Molecular Biosciences |
issn |
2296-889X |
publishDate |
2016-10-01 |
description |
Lysosomal serine carboxypeptidase Cathepsin A (CTSA) is a multifunctional enzyme with distinct protective and catalytic function. CTSA that is present in the lysosomal multienzyme complex facilitates correct lysosomal routing, stability and activation of betagalactosidase and alpha-neuraminidase. In addition, CTSA plays a role in the inactivation of bioactive peptides including bradykinin, substances P, oxytocin, angiotensin I and endothelin-I by cleavage of one or two amino acid(s) from the C-terminal ends. In this study, we aimed to elucidate the regulatory role of CTSA on bioactive peptides in a knock-in mouse model of CTSAS190A. We evaluated the levels of bradykinin, substances P, oxytocin, angiotensin I and endothelin-I in the kidney, liver, lung, brain and serum of the CTSAS190A mouse model at three- and six-months of age. Our results suggest that CTSA selectively contributes to the processing of bioactive peptides in different tissues of CTSAS190A mice compared to those of age-matched wild-type mice. |
topic |
Cathepsin A Mouse regulation Lysosome bioactive peptid |
url |
http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00068/full |
work_keys_str_mv |
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1716806783399362560 |