Mesenchymal Stem Cells Can Both Enhance and Inhibit the Cellular Response to DNA Immunization by Genes of Nonstructural Proteins of the Hepatitis C Virus

Mesenchymal Stem Cells Can Both Enhance and Inhibit the Cellular Response to DNA Immunization by Genes of Nonstructural Proteins of the Hepatitis C Virus

Despite extensive research, there is still no vaccine against the hepatitis C virus (HCV). The aim of this study was to investigate whether MSCs can exhibit adjuvant properties during DNA vaccination against hepatitis C. We used the pcNS3-NS5B plasmid encoding five nonstructural HCV proteins and MSC...

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Bibliographic Details
Main Authors: Olga V. Masalova, Ekaterina I. Lesnova, Regina R. Klimova, Alexander V. Ivanov, Alla A. Kushch
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stem cells (MSC)
DNA immunization
hepatitis C virus (HCV)
nonstructural HCV proteins
immune response
HCV vaccine
Online Access:https://www.mdpi.com/1422-0067/22/15/8121

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