Peroxisome proliferator-activated receptors-γ and hypertension: Lessons of the history of researches
The paper analyzes data from the clinical use of thiazolidinediones, human genetic observations and experiments with peroxisome proliferator-activated receptor (PPAR-α) gene removal, and also those on the role of PPAR-γ and -Β in the function of the vascular endothelium, sympathetic autonomic nervou...
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Format: | Article |
Language: | Russian |
Published: |
"Consilium Medicum" Publishing house
2013-09-01
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Series: | Терапевтический архив |
Subjects: | |
Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31384 |
Summary: | The paper analyzes data from the clinical use of thiazolidinediones, human genetic observations and experiments with peroxisome proliferator-activated receptor (PPAR-α) gene removal, and also those on the role of PPAR-γ and -Β in the function of the vascular endothelium, sympathetic autonomic nervous system, and renal sodium reabsorption. It is concluded that the tonic activity of PPAR is a universal protective mechanism counteracting the development of hypertension. |
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ISSN: | 0040-3660 2309-5342 |