Peroxisome proliferator-activated receptors-γ and hypertension: Lessons of the history of researches

The paper analyzes data from the clinical use of thiazolidinediones, human genetic observations and experiments with peroxisome proliferator-activated receptor (PPAR-α) gene removal, and also those on the role of PPAR-γ and -Β in the function of the vascular endothelium, sympathetic autonomic nervou...

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Main Author:	M S Rasin
Format:	Article
Language:	Russian
Published:	"Consilium Medicum" Publishing house 2013-09-01
Series:	Терапевтический архив
Subjects:	peroxisome proliferator-activated receptors-γ hypertension thiazolidinediones. ppar-γ
Online Access:	https://ter-arkhiv.ru/0040-3660/article/view/31384

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record_format	Article
spelling	doaj-90bb6f0c33d84e548a42e17904c153422020-11-25T03:04:45Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422013-09-0185911812328400Peroxisome proliferator-activated receptors-γ and hypertension: Lessons of the history of researchesM S RasinThe paper analyzes data from the clinical use of thiazolidinediones, human genetic observations and experiments with peroxisome proliferator-activated receptor (PPAR-α) gene removal, and also those on the role of PPAR-γ and -Β in the function of the vascular endothelium, sympathetic autonomic nervous system, and renal sodium reabsorption. It is concluded that the tonic activity of PPAR is a universal protective mechanism counteracting the development of hypertension.https://ter-arkhiv.ru/0040-3660/article/view/31384peroxisome proliferator-activated receptors-γhypertensionthiazolidinediones.ppar-γ
collection	DOAJ
language	Russian
format	Article
sources	DOAJ
author	M S Rasin
spellingShingle	M S Rasin Peroxisome proliferator-activated receptors-γ and hypertension: Lessons of the history of researches Терапевтический архив peroxisome proliferator-activated receptors-γ hypertension thiazolidinediones. ppar-γ
author_facet	M S Rasin
author_sort	M S Rasin
title	Peroxisome proliferator-activated receptors-γ and hypertension: Lessons of the history of researches
title_short	Peroxisome proliferator-activated receptors-γ and hypertension: Lessons of the history of researches
title_full	Peroxisome proliferator-activated receptors-γ and hypertension: Lessons of the history of researches
title_fullStr	Peroxisome proliferator-activated receptors-γ and hypertension: Lessons of the history of researches
title_full_unstemmed	Peroxisome proliferator-activated receptors-γ and hypertension: Lessons of the history of researches
title_sort	peroxisome proliferator-activated receptors-γ and hypertension: lessons of the history of researches
publisher	"Consilium Medicum" Publishing house
series	Терапевтический архив
issn	0040-3660 2309-5342
publishDate	2013-09-01
description	The paper analyzes data from the clinical use of thiazolidinediones, human genetic observations and experiments with peroxisome proliferator-activated receptor (PPAR-α) gene removal, and also those on the role of PPAR-γ and -Β in the function of the vascular endothelium, sympathetic autonomic nervous system, and renal sodium reabsorption. It is concluded that the tonic activity of PPAR is a universal protective mechanism counteracting the development of hypertension.
topic	peroxisome proliferator-activated receptors-γ hypertension thiazolidinediones. ppar-γ
url	https://ter-arkhiv.ru/0040-3660/article/view/31384
work_keys_str_mv	AT msrasin peroxisomeproliferatoractivatedreceptorsgandhypertensionlessonsofthehistoryofresearches
_version_	1724679952706568192

Peroxisome proliferator-activated receptors-γ and hypertension: Lessons of the history of researches

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