Organoids to Study Intestinal Nutrient Transport, Drug Uptake and Metabolism – Update to the Human Model and Expansion of Applications

Organoids to Study Intestinal Nutrient Transport, Drug Uptake and Metabolism – Update to the Human Model and Expansion of Applications

Intestinal transport and sensing processes and their interconnection to metabolism are relevant to pathologies such as malabsorption syndromes, inflammatory diseases, obesity and type 2 diabetes. Constituting a highly selective barrier, intestinal epithelial cells absorb, metabolize, and release nut...

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Bibliographic Details
Main Authors: Tamara Zietek, Pieter Giesbertz, Maren Ewers, Florian Reichart, Michael Weinmüller, Elisabeth Urbauer, Dirk Haller, Ihsan Ekin Demir, Güralp O. Ceyhan, Horst Kessler, Eva Rath
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
peptidomimetics
acylcarnitine
glucose absorption
live cell imaging
fatty acid oxidation
PEPT1
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.577656/full

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