Selective Targeting of Cancer-Associated Fibroblasts by Engineered H-Ferritin Nanocages Loaded with Navitoclax

Selective Targeting of Cancer-Associated Fibroblasts by Engineered H-Ferritin Nanocages Loaded with Navitoclax

Cancer-associated fibroblasts (CAFs) are key actors in regulating cancer progression. They promote tumor growth, metastasis formation, and induce drug resistance. For these reasons, they are emerging as potential therapeutic targets. Here, with the aim of developing CAF-targeted drug delivery agents...

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Bibliographic Details
Main Authors: Leopoldo Sitia, Arianna Bonizzi, Serena Mazzucchelli, Sara Negri, Cristina Sottani, Elena Grignani, Maria Antonietta Rizzuto, Davide Prosperi, Luca Sorrentino, Carlo Morasso, Raffaele Allevi, Marta Sevieri, Filippo Silva, Marta Truffi, Fabio Corsi
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
cancer-associated fibroblasts
fibroblast activation protein
targeted nanoparticles
H-ferritin
navitoclax
Online Access:https://www.mdpi.com/2073-4409/10/2/328

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