Sequence variations of the EGR4 gene in Korean men with spermatogenesis impairment

Sequence variations of the EGR4 gene in Korean men with spermatogenesis impairment

Abstract Background Egr4 is expressed in primary and secondary spermatocytes in adult mouse testes and has a crucial role in regulating germ cell maturation. The functional loss of Egr4 blocks spermatogenesis, significantly reducing the number of spermatozoa that are produced. In this study, we exam...

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Bibliographic Details
Main Authors: Se Ra Sung, Seung Hun Song, Kyung Min Kang, Ji Eun Park, Yeo Jung Nam, Yun-jeong Shin, Dong Hyun Cha, Ju Tae Seo, Tae Ki Yoon, Sung Han Shim
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Medical Genetics
Subjects:
EGR4 gene
Sequence variation
Impaired spermatogenesis
Male infertility
Online Access:http://link.springer.com/article/10.1186/s12881-017-0408-5

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