A Comparative Study of Liquid Nitrogen Cryotherapy as Monotherapy versus in Combination with Podophyllin in the Treatment of Condyloma Acuminata
Introduction: Condyloma Acuminata (CA) is a common viral sexually transmitted disease. Although various treatment modalities are available for treating CA, but none of them can achieve 100% response rate. In a search for better response rate and less recurrence rate, the combination of cytotoxic...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2017-03-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/9339/23797_CE[Ra]_F(DK)_PF1(MS_DK)_PFA(DK)_PF2(___DK).pdf |
Summary: | Introduction: Condyloma Acuminata (CA) is a common viral
sexually transmitted disease. Although various treatment
modalities are available for treating CA, but none of them can
achieve 100% response rate. In a search for better response
rate and less recurrence rate, the combination of cytotoxic
agent Podophyllin with ablative liquid nitrogen cryotherapy was
evaluated over cryotherapy alone.
Aim: To evaluate the synergistic effect of Podophyllin as a
chemotherapeutic adjunct to an ablative therapy of liquid
nitrogen cryotherapy versus liquid nitrogen cryotherapy alone
in the treatment of CA.
Materials and Methods: Sixty patients with multiple CA were
randomly assigned to two groups in the study. Thirty patients in
group A received double freeze thaw cycle of 25 seconds of liquid
nitrogen cryotherapy. Thirty patients in Group B were subjected
to liquid nitrogen cryotherapy in a similar manner followed by
application of not more than 0.5 ml of 25% Podophyllin solution.
All patients were followed up at 1, 4, 8, 12 and 24 weeks after
the treatment to monitor the response to therapy and evaluation
for any recurrence. When the number of unresponsive lesions
were more than 30% of original lesions at 4 weeks follow-up,
then the whole procedure was repeated again.
Results: The complete response rate and the recurrence rate
in the Group B in our study were comparable to Group A as the
difference was statistically insignificant. But the differentiating
point was that the similar results were obtained in Group B with
an average1.2 sessions per patient in comparison to an average
of 1.67 sessions per patient in Group A.
Conclusion: Cryotherapy represents a simple, safe and effective
regimen for the treatment of multiple CA which in combination
with Podophyllin is even more effective as a single session
procedure; thereby shortening the treatment regimen. |
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ISSN: | 2249-782X 0973-709X |