Synthesis, Characterization and Biological Evaluation of Succinate Prodrugs of Curcuminoids for Colon Cancer Treatment

Synthesis, Characterization and Biological Evaluation of Succinate Prodrugs of Curcuminoids for Colon Cancer Treatment

A novel series of succinyl derivatives of three curcuminoids were synthesized as potential prodrugs. Symmetrical (curcumin and bisdesmethoxycurcumin) and unsymmetrical (desmethoxycurcumin) curcuminoids were prepared through aldol condensation of 2,4-pentanedione with different benzaldehydes. Esterif...

Full description

Bibliographic Details
Main Authors: Pornchai Rojsitthisak, Ubonthip Nimmannit, Sumrit Wacharasindhu, Wisut Wichitnithad
Format: Article
Language:English
Published: MDPI AG 2011-02-01
Series:Molecules
Subjects:
curcumin
prodrug
succinylation
stability
hydrolysis
Online Access:http://www.mdpi.com/1420-3049/16/2/1888/

Similar Items

Similar Items