Linear B-Cell Epitopes in Human Norovirus GII.4 Capsid Protein Elicit Blockade Antibodies

Linear B-Cell Epitopes in Human Norovirus GII.4 Capsid Protein Elicit Blockade Antibodies

Human norovirus (HuNoV) is the leading cause of nonbacterial gastroenteritis worldwide with the GII.4 genotype accounting for over 80% of infections. The major capsid protein of GII.4 variants is evolving rapidly, resulting in new epidemic variants with altered antigenic potentials that must be cons...

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Bibliographic Details
Main Authors: Hassan Moeini, Suliman Qadir Afridi, Sainitin Donakonda, Percy A. Knolle, Ulrike Protzer, Dieter Hoffmann
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Vaccines
Subjects:
norovirus
GII.4 genotype
molecular dynamic simulation
linear blockade epitope
Online Access:https://www.mdpi.com/2076-393X/9/1/52

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