Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial
Hydroxyapatite (HAp) is a widely used biomaterial because it is the main inorganic component of human bone and teeth. Rubidium (Rb) is a vital trace metal element in human body, and has been reported to possess antibacterial ability and can promote osteoblasts proliferation and differentiation. In t...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2021-01-01
|
Series: | Journal of Asian Ceramic Societies |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/21870764.2020.1865861 |
id |
doaj-90e14f842cb04e50951f802659f8aa01 |
---|---|
record_format |
Article |
spelling |
doaj-90e14f842cb04e50951f802659f8aa012021-05-03T04:11:45ZengTaylor & Francis GroupJournal of Asian Ceramic Societies2187-07642021-01-019132333310.1080/21870764.2020.18658611865861Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterialYanjun Liu0Yanni Tan1Jiangsong Wu2Central South UniversityCentral South UniversityCentral South UniversityHydroxyapatite (HAp) is a widely used biomaterial because it is the main inorganic component of human bone and teeth. Rubidium (Rb) is a vital trace metal element in human body, and has been reported to possess antibacterial ability and can promote osteoblasts proliferation and differentiation. In this work, nanoscale hydroxyapatite particles doped with different contents of Rb (Rb-nHAp) were successfully prepared by hydrothermal method. X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR) were used to characterize the structure and morphology of the synthesized Rb-nHAp. XRD and FT-IR results show that the powders were pure HAp with good crystal structure and no other phase or impurity. SEM and TEM observations indicate that Rb-nHAp powders exhibit a homogeneous rod-like morphology, which were 50 ~ 300 nm in size. The in vitro results show that 3% and 5% Rb-nHAp exhibited enhanced proliferation and differentiation to MG-63 cells than pure HAp at day 7 or longer. In vitro bacterial proliferation assay shows that Rb-nHAp powders exhibit higher inhibition against the both bacteria. In conclusion, doping Rb could simultaneously endow nano-hydroxyapatite (nHAp) with favorable cytocompatibility and antibacterial capacity. Rb-nHAp can be a promising material for biomedical applications.http://dx.doi.org/10.1080/21870764.2020.1865861rubidiumhydroxyapatiteion modificationcytocompatibilityantibacterial capacity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yanjun Liu Yanni Tan Jiangsong Wu |
spellingShingle |
Yanjun Liu Yanni Tan Jiangsong Wu Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial Journal of Asian Ceramic Societies rubidium hydroxyapatite ion modification cytocompatibility antibacterial capacity |
author_facet |
Yanjun Liu Yanni Tan Jiangsong Wu |
author_sort |
Yanjun Liu |
title |
Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial |
title_short |
Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial |
title_full |
Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial |
title_fullStr |
Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial |
title_full_unstemmed |
Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial |
title_sort |
rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial |
publisher |
Taylor & Francis Group |
series |
Journal of Asian Ceramic Societies |
issn |
2187-0764 |
publishDate |
2021-01-01 |
description |
Hydroxyapatite (HAp) is a widely used biomaterial because it is the main inorganic component of human bone and teeth. Rubidium (Rb) is a vital trace metal element in human body, and has been reported to possess antibacterial ability and can promote osteoblasts proliferation and differentiation. In this work, nanoscale hydroxyapatite particles doped with different contents of Rb (Rb-nHAp) were successfully prepared by hydrothermal method. X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR) were used to characterize the structure and morphology of the synthesized Rb-nHAp. XRD and FT-IR results show that the powders were pure HAp with good crystal structure and no other phase or impurity. SEM and TEM observations indicate that Rb-nHAp powders exhibit a homogeneous rod-like morphology, which were 50 ~ 300 nm in size. The in vitro results show that 3% and 5% Rb-nHAp exhibited enhanced proliferation and differentiation to MG-63 cells than pure HAp at day 7 or longer. In vitro bacterial proliferation assay shows that Rb-nHAp powders exhibit higher inhibition against the both bacteria. In conclusion, doping Rb could simultaneously endow nano-hydroxyapatite (nHAp) with favorable cytocompatibility and antibacterial capacity. Rb-nHAp can be a promising material for biomedical applications. |
topic |
rubidium hydroxyapatite ion modification cytocompatibility antibacterial capacity |
url |
http://dx.doi.org/10.1080/21870764.2020.1865861 |
work_keys_str_mv |
AT yanjunliu rubidiumdopednanohydroxyapatitewithcytocompatibilityandantibacterial AT yannitan rubidiumdopednanohydroxyapatitewithcytocompatibilityandantibacterial AT jiangsongwu rubidiumdopednanohydroxyapatitewithcytocompatibilityandantibacterial |
_version_ |
1721484377551011840 |