Tribbles Homolog 3-Mediated Vascular Insulin Resistance Contributes to Hypoxic Pulmonary Hypertension in Intermittent Hypoxia Rat Model

Tribbles Homolog 3-Mediated Vascular Insulin Resistance Contributes to Hypoxic Pulmonary Hypertension in Intermittent Hypoxia Rat Model

This study aimed to investigate the role of vascular insulin resistance (VIR) and Tribbles homolog 3 (TRIB3) in the pathogenesis of hypoxia-induced pulmonary hypertension (HPH). Rats were subjected to low air pressure and low oxygen intermittently for 4 weeks to induce HPH. The mean right ventricula...

Full description

Bibliographic Details
Main Authors: Fang Fan, Jinxiao He, Hui Su, Haifeng Zhang, Hao Wang, Qianqian Dong, Minghua Zeng, Wenjuan Xing, Xin Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Physiology
Subjects:
hypoxic pulmonary hypertension
proliferator-activated receptor gamma
pulmonary arterial endothelium
vascular insulin resistance
Tribbles homolog 3
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.542146/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.542146/full

Similar Items