Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?

• Main Authors: Fariba Iraji, Nabet Tajmirriahi, Iman Momeni, Kioumars Jamshidi, Fazlollah Hashemzehi, Amir Hossein Siadat, Alireza Asemi Esfahani
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2016-01-01
• Series: Advanced Biomedical Research
• Subjects: Desmoglein; pemphigus vulgaris; prolactin
• Online Access: http://www.advbiores.net/article.asp?issn=2277-9175;year=2016;volume=5;issue=1;spage=206;epage=206;aulast=Iraji

Background: Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis. Recent studies showed an etiologic effect for prolactin in the pemphigus vulgaris. This study aimed to quantify the correlation between serum prolactin levels and anti-desmoglein antibodies in patients with pemphigus vulgaris. Materials and Methods: Prolactin and antibodies against desmoglein 1 and 3 measured with ELISA in 14 new subjects of pemphigus vulgaris. Results: There was no statistically significant relation between both serum prolactin and anti-desmoglein1 levels (r = 0.02, P = 0.47) and serum prolactin and anti-desmoglein 3 levels (r= -0.09, P = 0.38). Conclusion: This study indicates that no correlation was found between serum prolactin levels and anti-desmoglein 1 levels and serum prolactin and anti-desmoglein 3 levels. However, other studies should be initiated regarding exact molecular and cellular effects of prolactin in the pathogenesis of pemphigus vulgaris.