Research progress in sonodynamic therapy

• Main Authors: LAI Kexin, TIAN Ya, WU Huixia
• Format: Article
• Language: English
• Published: Academic Journals Center of Shanghai Normal University 2020-08-01
• Series: Journal of Shanghai Normal University (Natural Sciences)
• Subjects: sonodynamic therapy (sdt); sonosensitizers; nanotechnology
• Online Access: http://qktg.shnu.edu.cn/zrb/shsfqkszrb/ch/reader/view_abstract.aspx?file_no=20200406

Sonodynamic therapy(SDT)works by the synergistic effect of ultrasound and sonosensitizers to kill cancer cells through multiple mechanisms.As a mechanical wave, ultrasound can penetrate deep tissues.Compared with traditional treatment methods, SDT uses ultrasound to activate the sonosensitizers to produce local toxicity and causes less damage to normal cells and tissues. Sonosensitizers play an important role in the process of SDT. Due to the biological defects of the traditional organic sonosensitizers, the major research direction is to combine sonosensitizers with nanotechnology by using nanocarriersor developing new inorganic sonosensitizers.So far, SDT is still in the preclinical and clinical research stage.Recent <i>in vitro</i> and <i>in vivo</i> studies have showed that SDT can kill a variety of cancer cells and have broad application prospects.We briefly described the mechanism of SDT, the type of sonosensitizers and the current applications of SDT.