δ-Opioid receptor as a potential therapeutic target for ischemic stroke
Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels. Despite having advancement in the use of thrombolytic and clot removal medicine, significant numbers of stroke pati...
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Wolters Kluwer Medknow Publications
2020-01-01
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doaj-90faf1200e8446b883344569174e93922020-11-25T03:19:24ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742020-01-01151202410.4103/1673-5374.264443δ-Opioid receptor as a potential therapeutic target for ischemic strokeKalpana SubediHongmin WangIschemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels. Despite having advancement in the use of thrombolytic and clot removal medicine, significant numbers of stroke patients are still left out without option for treatment. In this review, we summarize recent research work on the activation of δ-opioid receptor as a strategy for treating ischemic stroke-caused neuronal injury. Moreover, as activation of δ-opioid receptor by a non-peptidic δ-opioid receptor agonist also modulates the expression, maturation and processing of amyloid precursor protein and β-secretase activity, the potential role of these effects on ischemic stroke caused dementia or Alzheimer’s disease are also discussed.http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=1;spage=20;epage=24;aulast=Subediagonist; AKT; amyloid precursor protein; BDNF; ischemic stroke; neuroprotection; δ-opioid receptor; p38 MAPK; PI3K; TrkB |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kalpana Subedi Hongmin Wang |
spellingShingle |
Kalpana Subedi Hongmin Wang δ-Opioid receptor as a potential therapeutic target for ischemic stroke Neural Regeneration Research agonist; AKT; amyloid precursor protein; BDNF; ischemic stroke; neuroprotection; δ-opioid receptor; p38 MAPK; PI3K; TrkB |
author_facet |
Kalpana Subedi Hongmin Wang |
author_sort |
Kalpana Subedi |
title |
δ-Opioid receptor as a potential therapeutic target for ischemic stroke |
title_short |
δ-Opioid receptor as a potential therapeutic target for ischemic stroke |
title_full |
δ-Opioid receptor as a potential therapeutic target for ischemic stroke |
title_fullStr |
δ-Opioid receptor as a potential therapeutic target for ischemic stroke |
title_full_unstemmed |
δ-Opioid receptor as a potential therapeutic target for ischemic stroke |
title_sort |
δ-opioid receptor as a potential therapeutic target for ischemic stroke |
publisher |
Wolters Kluwer Medknow Publications |
series |
Neural Regeneration Research |
issn |
1673-5374 |
publishDate |
2020-01-01 |
description |
Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels. Despite having advancement in the use of thrombolytic and clot removal medicine, significant numbers of stroke patients are still left out without option for treatment. In this review, we summarize recent research work on the activation of δ-opioid receptor as a strategy for treating ischemic stroke-caused neuronal injury. Moreover, as activation of δ-opioid receptor by a non-peptidic δ-opioid receptor agonist also modulates the expression, maturation and processing of amyloid precursor protein and β-secretase activity, the potential role of these effects on ischemic stroke caused dementia or Alzheimer’s disease are also discussed. |
topic |
agonist; AKT; amyloid precursor protein; BDNF; ischemic stroke; neuroprotection; δ-opioid receptor; p38 MAPK; PI3K; TrkB |
url |
http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=1;spage=20;epage=24;aulast=Subedi |
work_keys_str_mv |
AT kalpanasubedi dopioidreceptorasapotentialtherapeutictargetforischemicstroke AT hongminwang dopioidreceptorasapotentialtherapeutictargetforischemicstroke |
_version_ |
1724622548822392832 |