Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling

Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling

Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment...

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Main Authors: Luca Genovese, Andrea Brendolan
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2016/8419104
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spelling doaj-90fd7d614e524466ba1538ec5a8e88b72020-11-24T21:03:18ZengHindawi LimitedStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/84191048419104Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue RemodelingLuca Genovese0Andrea Brendolan1Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyDivision of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalySecondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear.http://dx.doi.org/10.1155/2016/8419104
collection DOAJ
language English
format Article
sources DOAJ
author Luca Genovese
Andrea Brendolan
spellingShingle Luca Genovese
Andrea Brendolan
Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling
Stem Cells International
author_facet Luca Genovese
Andrea Brendolan
author_sort Luca Genovese
title Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling
title_short Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling
title_full Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling
title_fullStr Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling
title_full_unstemmed Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling
title_sort lymphoid tissue mesenchymal stromal cells in development and tissue remodeling
publisher Hindawi Limited
series Stem Cells International
issn 1687-966X
1687-9678
publishDate 2016-01-01
description Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear.
url http://dx.doi.org/10.1155/2016/8419104
work_keys_str_mv AT lucagenovese lymphoidtissuemesenchymalstromalcellsindevelopmentandtissueremodeling
AT andreabrendolan lymphoidtissuemesenchymalstromalcellsindevelopmentandtissueremodeling
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