Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides

Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides

Brain development is guided by the interactions between the genetic blueprint and the environment. Epigenetic mechanisms, especially DNA methylation, can mediate these interactions and may also trigger long-lasting adaptations in developmental programs that increase the risk of major depressive diso...

Full description

Bibliographic Details
Main Authors:	Anke Hoffmann, Vincenza Sportelli, Michael Ziller, Dietmar Spengler
Format:	Article
Language:	English
Published:	MDPI AG 2017-08-01
Series:	International Journal of Molecular Sciences
Subjects:	epigenomics early life adversity major depression schizophrenia GWAS EWAS meQTL eQTL
Online Access:	https://www.mdpi.com/1422-0067/18/8/1711

Similar Items

Characterization of cross-tissue genetic-epigenetic effects and their patterns in schizophrenia
by: Dongdong Lin, et al.
Published: (2018-02-01)

Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci
by: Richa Gupta, et al.
Published: (2019-01-01)

Genetic impacts on DNA methylation: research findings and future perspectives
by: Sergio Villicaña, et al.
Published: (2021-04-01)

Integrated Analysis of Summary Statistics to Identify Pleiotropic Genes and Pathways for the Comorbidity of Schizophrenia and Cardiometabolic Disease
by: Hao Liu, et al.
Published: (2020-04-01)

The impact of cell type and context-dependent regulatory variants on human immune traits
by: Zepeng Mu, et al.
Published: (2021-04-01)

Revisiting genetic artifacts on DNA methylation microarrays exposes novel biological implications
by: Benjamin Planterose Jiménez, et al.
Published: (2021-09-01)

eQTpLot: a user-friendly R package for the visualization of colocalization between eQTL and GWAS signals
by: Theodore G. Drivas, et al.
Published: (2021-07-01)

Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain
by: Dena G. Hernandez, et al.
Published: (2012-07-01)

Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative Analyses
by: Ancha Baranova, et al.
Published: (2021-09-01)

DNA Methylation in Ovarian Cancer Susceptibility
by: Brett M. Reid, et al.
Published: (2021-12-01)

Integrate GWAS, eQTL, and mQTL Data to Identify Alzheimer’s Disease-Related Genes
by: Tianyi Zhao, et al.
Published: (2019-10-01)

Mapping QTL for white striping in relation to breast muscle yield and meat quality traits in broiler chickens
by: Eva Pampouille, et al.
Published: (2018-03-01)

Epigenome-Wide Comparative Study Reveals Key Differences Between Mixed Connective Tissue Disease and Related Systemic Autoimmune Diseases
by: Elena Carnero-Montoro, et al.
Published: (2019-08-01)

The NCAN gene: schizophrenia susceptibility and cognitive dysfunction
by: Wang P, et al.
Published: (2016-11-01)

Re-Conceptualizing Genetic Influence in GxE Studies: Does Inherited Sensitivity to Environmental Influence Moderate the Indirect Effect of Parent Knowledge on Future Drinking?
Published: (2020)

The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction
by: Joel Lavinsky, et al.
Published: (2016-10-01)

Genetic Mechanism Revealed of Age-Related Macular Degeneration Based on Fusion of Statistics and Machine Learning Method
by: Yongyi Du, et al.
Published: (2021-08-01)

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts
by: Benjamin H. Mullin, et al.
Published: (2020-03-01)

To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes
by: Amelia D. Wallace, et al.
Published: (2018-08-01)

The interaction of Epstein-Barr virus encoded transcription factor EBNA2 with multiple sclerosis risk loci is dependent on the risk genotype
by: Jeremy Thomas Keane, et al.
Published: (2021-09-01)

Disentangling the genetics of sarcopenia: prioritization of NUDT3 and KLF5 as genes for lean mass & HLA-DQB1-AS1 for hand grip strength with the associated enhancing SNPs & a scoring system
by: Abhishek Narain Singh, et al.
Published: (2020-02-01)

Identification of Alzheimer's Disease-Related Genes Based on Data Integration Method
by: Yang Hu, et al.
Published: (2019-01-01)

Identification of Causal Genes of COVID-19 Using the SMR Method
by: Yan Zong, et al.
Published: (2021-07-01)

Identification of Gingivitis-Related Genes Across Human Tissues Based on the Summary Mendelian Randomization
by: Jiahui Zhang, et al.
Published: (2021-05-01)

Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data
by: Fei Shen, et al.
Published: (2021-02-01)

Systems biology and bioinformatics approach to identify gene signatures, pathways and therapeutic targets of Alzheimer's disease
by: Utpala Nanda Chowdhury, et al.
Published: (2020-01-01)

Highly diversified core promoters in the human genome and their effects on gene expression and disease predisposition
by: Hemant Gupta, et al.
Published: (2020-11-01)

Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
by: T. Maroilley, et al.
Published: (2017-12-01)

Enhancing the Promise of Drug Repositioning through Genetics
by: Jayne-Louise E. Pritchard, et al.
Published: (2017-12-01)

Integrative Analysis Identifies Genetic Variants Associated With Autoimmune Diseases Affecting Putative MicroRNA Binding Sites
by: Rodrigo C. de Almeida, et al.
Published: (2018-04-01)

RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs
by: Jiyoun Yeo, et al.
Published: (2018-03-01)

Identification of New Genes and Loci Associated With Bone Mineral Density Based on Mendelian Randomization
by: Yijun Liu, et al.
Published: (2021-09-01)

Large-scale East-Asian eQTL Mapping Reveals Novel Candidate Genes for LD Mapping and the Genomic Landscape of Transcriptional Effects of Sequence Variants
by: Narahara, Maiko
Published: (2015)

Alternative polyadenylation mediates genetic regulation of gene expression
by: Briana E Mittleman, et al.
Published: (2020-06-01)

Learning from Fifteen Years of Genome-Wide Association Studies in Age-Related Macular Degeneration
by: Tobias Strunz, et al.
Published: (2020-10-01)

From GWAS to Gene: Transcriptome-Wide Association Studies and Other Methods to Functionally Understand GWAS Discoveries
by: Binglan Li, et al.
Published: (2021-09-01)

Integrated Genome-Wide Analysis of MicroRNA Expression Quantitative Trait Loci in Pig Longissimus Dorsi Muscle
by: Kaitlyn R. Daza, et al.
Published: (2021-03-01)

Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus
by: Silva Kasela, et al.
Published: (2021-08-01)

Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes
by: Yehudit Hasin-Brumshtein, et al.
Published: (2016-09-01)

eQTL discovery and their association with severe equine asthma in European Warmblood horses
by: Victor C. Mason, et al.
Published: (2018-08-01)