Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington’s Disease Pre-clinical Model

Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington’s Disease Pre-clinical Model

Although several agents have been identified to provide therapeutic benefits in Huntington disease (HD), the number of conventionally used treatments remains limited and only symptomatic. Thus, it is plausible that the need to identify new therapeutic targets for the development of alternative and m...

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Bibliographic Details
Main Authors: Alba Di Pardo, Giuseppe Pepe, Salvatore Castaldo, Federico Marracino, Luca Capocci, Enrico Amico, Michele Madonna, Susy Giova, Se Kyoo Jeong, Bu-Mahn Park, Byeong Deog Park, Vittorio Maglione
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
HD
K6PC-5
SPHK1
aggregates
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00100/full

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