Clinical profile of children with developmental delay and microcephaly
Aim: To study the profile of children with developmental delay and microcephaly. Materials and Methods: Children attending child development clinic with developmental delay were evaluated as per protocol. Z scores of head circumference were calculated using WHO charts. Clinical, radiological and eti...
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2013-07-01
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Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/0976-3147.118781 |
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doaj-911bef3148e44636acf13c796c0f4cd62021-04-02T15:58:51ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Neurosciences in Rural Practice0976-31470976-31552013-07-01040328829110.4103/0976-3147.118781Clinical profile of children with developmental delay and microcephalyAnju Aggarwal0Hema Mittal1Rahul Patil2Sanjib Debnath3Anuradha Rai4Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, IndiaDepartment of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, IndiaDepartment of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, IndiaDepartment of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, IndiaDepartment of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, IndiaAim: To study the profile of children with developmental delay and microcephaly. Materials and Methods: Children attending child development clinic with developmental delay were evaluated as per protocol. Z scores of head circumference were calculated using WHO charts. Clinical, radiological and etiological profile of those with microcephaly and those without was compared. Results: Of the 414 children with developmental delay 231 had microcephaly (z score ≤ -3). Mean age of children with microcephaly was 35.1 ± 27.9 months (range 4-184), males (72.7%). Comorbidities were epilepsy (42.9%), visual abnormality (26.4%), hearing abnormality (16.9%). Mean DQ was 29.75 + 17.8 in those with microcephaly was significantly lower compared to the rest (P = 0.002). Secondary microcephaly was associated with cerebral palsy in 69.7%. Other causes were congenital infections (4), inborn error of metabolism (3), post-meningoencephalitis (5), malformations (12), and syndromic (13). Neuroimaging was done in 118 (51.1%) cases of which 104 (88.1%) were abnormal. On comparison children with microcephaly had more epilepsy, lower developmental quotient, vision abnormalities findings as compared to normocephalic children with developmental delay (P &003E; 0.05). Conclusion: Microcephaly was associated with lower, DQ, higher comorbidities in children with developmental delay. Spastic CP is commonly associated with microcephaly.http://www.thieme-connect.de/DOI/DOI?10.4103/0976-3147.118781cerebral palsydevelopmental delayetiologymicrocephaly |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anju Aggarwal Hema Mittal Rahul Patil Sanjib Debnath Anuradha Rai |
spellingShingle |
Anju Aggarwal Hema Mittal Rahul Patil Sanjib Debnath Anuradha Rai Clinical profile of children with developmental delay and microcephaly Journal of Neurosciences in Rural Practice cerebral palsy developmental delay etiology microcephaly |
author_facet |
Anju Aggarwal Hema Mittal Rahul Patil Sanjib Debnath Anuradha Rai |
author_sort |
Anju Aggarwal |
title |
Clinical profile of children with developmental delay and microcephaly |
title_short |
Clinical profile of children with developmental delay and microcephaly |
title_full |
Clinical profile of children with developmental delay and microcephaly |
title_fullStr |
Clinical profile of children with developmental delay and microcephaly |
title_full_unstemmed |
Clinical profile of children with developmental delay and microcephaly |
title_sort |
clinical profile of children with developmental delay and microcephaly |
publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
series |
Journal of Neurosciences in Rural Practice |
issn |
0976-3147 0976-3155 |
publishDate |
2013-07-01 |
description |
Aim: To study the profile of children with developmental delay and microcephaly. Materials and Methods: Children attending child development clinic with developmental delay were evaluated as per protocol. Z scores of head circumference were calculated using WHO charts. Clinical, radiological and etiological profile of those with microcephaly and those without was compared. Results: Of the 414 children with developmental delay 231 had microcephaly (z score ≤ -3). Mean age of children with microcephaly was 35.1 ± 27.9 months (range 4-184), males (72.7%). Comorbidities were epilepsy (42.9%), visual abnormality (26.4%), hearing abnormality (16.9%). Mean DQ was 29.75 + 17.8 in those with microcephaly was significantly lower compared to the rest (P = 0.002). Secondary microcephaly was associated with cerebral palsy in 69.7%. Other causes were congenital infections (4), inborn error of metabolism (3), post-meningoencephalitis (5), malformations (12), and syndromic (13). Neuroimaging was done in 118 (51.1%) cases of which 104 (88.1%) were abnormal. On comparison children with microcephaly had more epilepsy, lower developmental quotient, vision abnormalities findings as compared to normocephalic children with developmental delay (P &003E; 0.05). Conclusion: Microcephaly was associated with lower, DQ, higher comorbidities in children with developmental delay. Spastic CP is commonly associated with microcephaly. |
topic |
cerebral palsy developmental delay etiology microcephaly |
url |
http://www.thieme-connect.de/DOI/DOI?10.4103/0976-3147.118781 |
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