Structure and function of Tec family kinase Itk
Itk is a member of the Tec family of kinases that is expressed predominantly in T cells. Itk regulates the T cell receptor signaling pathway to modulate T cell development and T helper cell differentiation, particularly Th2 differentiation. Itk is also important for the development and function of i...
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De Gruyter
2011-06-01
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| Series: | Biomolecular Concepts |
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| Online Access: | https://doi.org/10.1515/bmc.2011.020 |
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doaj-911e5c6f27a1438b9f92c4e2954af30e2021-09-05T20:42:37ZengDe GruyterBiomolecular Concepts1868-50211868-503X2011-06-012322323210.1515/bmc.2011.020Structure and function of Tec family kinase ItkQi QianKannan Arun KumarAugust Avery0Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853-6401, USAItk is a member of the Tec family of kinases that is expressed predominantly in T cells. Itk regulates the T cell receptor signaling pathway to modulate T cell development and T helper cell differentiation, particularly Th2 differentiation. Itk is also important for the development and function of iNKT cells. In this review we discuss current progress on our understanding of the structure, activation and signaling pathway of Itk, in addition to inhibitors that have been developed, which target this kinase. We also place in context the function of Itk, available inhibitors and potential use in treating disease.https://doi.org/10.1515/bmc.2011.020kinaset cellstec |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Qi Qian Kannan Arun Kumar August Avery |
| spellingShingle |
Qi Qian Kannan Arun Kumar August Avery Structure and function of Tec family kinase Itk Biomolecular Concepts kinase t cells tec |
| author_facet |
Qi Qian Kannan Arun Kumar August Avery |
| author_sort |
Qi Qian |
| title |
Structure and function of Tec family kinase Itk |
| title_short |
Structure and function of Tec family kinase Itk |
| title_full |
Structure and function of Tec family kinase Itk |
| title_fullStr |
Structure and function of Tec family kinase Itk |
| title_full_unstemmed |
Structure and function of Tec family kinase Itk |
| title_sort |
structure and function of tec family kinase itk |
| publisher |
De Gruyter |
| series |
Biomolecular Concepts |
| issn |
1868-5021 1868-503X |
| publishDate |
2011-06-01 |
| description |
Itk is a member of the Tec family of kinases that is expressed predominantly in T cells. Itk regulates the T cell receptor signaling pathway to modulate T cell development and T helper cell differentiation, particularly Th2 differentiation. Itk is also important for the development and function of iNKT cells. In this review we discuss current progress on our understanding of the structure, activation and signaling pathway of Itk, in addition to inhibitors that have been developed, which target this kinase. We also place in context the function of Itk, available inhibitors and potential use in treating disease. |
| topic |
kinase t cells tec |
| url |
https://doi.org/10.1515/bmc.2011.020 |
| work_keys_str_mv |
AT qiqian structureandfunctionoftecfamilykinaseitk AT kannanarunkumar structureandfunctionoftecfamilykinaseitk AT augustavery structureandfunctionoftecfamilykinaseitk |
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1717785410829025280 |