Integrative analysis of breast cancer profiles in TCGA by TNBC subgrouping reveals novel microRNA-specific clusters, including miR-17-92a, distinguishing basal-like 1 and basal-like 2 TNBC subtypes

Integrative analysis of breast cancer profiles in TCGA by TNBC subgrouping reveals novel microRNA-specific clusters, including miR-17-92a, distinguishing basal-like 1 and basal-like 2 TNBC subtypes

Abstract Background The term triple-negative breast cancer (TNBC) is used to describe breast cancers without expression of estrogen receptor, progesterone receptor or HER2 amplification. To advance targeted treatment options for TNBC, it is critical that the subtypes within this classification be de...

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Bibliographic Details
Main Authors: Karel Kalecky, Rebecca Modisette, Samantha Pena, Young-Rae Cho, Joseph Taube
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Cancer
Subjects:
Breast cancer
Molecular subtypes
TNBCtype
microRNA
miR-17
INPP4B
Online Access:http://link.springer.com/article/10.1186/s12885-020-6600-6

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