p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.

p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.

BACKGROUND: p16(INK4a) and p21(WAF1) are two independent cyclin-dependent kinase inhibitors encoded by the CDKN2A and CDKN1A genes, respectively. p16(INK4a) and p21(WAF1) are similarly involved in various anti-cancer processes, including the regulation of the critical G1 to S phase transition of the...

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Bibliographic Details
Main Authors: Huda H Al-Khalaf, Abdelilah Aboussekhra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3720951?pdf=render

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