Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion.

Cardiovascular disease is the leading cause of death worldwide, mainly due to an increasing prevalence of atherosclerosis characterized by inflammatory plaques. Plaques with high levels of macrophage infiltration are considered "vulnerable" while those that do not have significant inflamma...

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Bibliographic Details
Main Authors: Ihab Abd-Elrahman, Hisanori Kosuge, Tommy Wises Sadan, Yael Ben-Nun, Karen Meir, Chen Rubinstein, Matthew Bogyo, Michael V McConnell, Galia Blum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4988760?pdf=render