Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite
Hydroxyapatite (HA) co-doped with Zn2+ and F− ions was synthesized by precipitation method for the first time in this study. FTIR spectroscopy revealed Zn2+ and F− ions incorporation into HA structure. Co-doping of Zn2+ and F− ions decreased unit cell volume of HA and decreased grain sizes. Zn2+ or...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-08-01
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| Series: | Progress in Natural Science: Materials International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1002007114000823 |
| Summary: | Hydroxyapatite (HA) co-doped with Zn2+ and F− ions was synthesized by precipitation method for the first time in this study. FTIR spectroscopy revealed Zn2+ and F− ions incorporation into HA structure. Co-doping of Zn2+ and F− ions decreased unit cell volume of HA and decreased grain sizes. Zn2+ or 5 mol% F− addition into HA significantly improved its density. Microhardness was increased with Zn2+ addition and further increase was detected with F− co-doping. Zn2+ and F− co-doped samples had higher fracture toughness than pure HA. Zn2+ incorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells, and further increase was observed with 1 mol% F− addition. With superior mechanical properties and biological response 2Zn1F is a good candidate for biomedical applications. |
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| ISSN: | 1002-0071 |