Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

• Main Authors: Idil Uysal, Feride Severcan, Aysen Tezcaner, Zafer Evis
• Format: Article
• Language: English
• Published: Elsevier 2014-08-01
• Series: Progress in Natural Science: Materials International
• Subjects: Hydroxyapatite; Co-doping; Microstructure; Microhardness; Biocompatibility
• Online Access: http://www.sciencedirect.com/science/article/pii/S1002007114000823

Hydroxyapatite (HA) co-doped with Zn2+ and F− ions was synthesized by precipitation method for the first time in this study. FTIR spectroscopy revealed Zn2+ and F− ions incorporation into HA structure. Co-doping of Zn2+ and F− ions decreased unit cell volume of HA and decreased grain sizes. Zn2+ or 5 mol% F− addition into HA significantly improved its density. Microhardness was increased with Zn2+ addition and further increase was detected with F− co-doping. Zn2+ and F− co-doped samples had higher fracture toughness than pure HA. Zn2+ incorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells, and further increase was observed with 1 mol% F− addition. With superior mechanical properties and biological response 2Zn1F is a good candidate for biomedical applications.