Essential Genes Embody Increased Mutational Robustness to Compensate for the Lack of Backup Genetic Redundancy.
Genetic robustness is a hallmark of cells, occurring through many mechanisms and at many levels. Essential genes lack the common robustness mechanism of genetic redundancy (i.e., existing alongside other genes with the same function), and thus appear at first glance to leave cells highly vulnerable...
Main Authors: | Osher Cohen, Matthew Oberhardt, Keren Yizhak, Eytan Ruppin |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5173180?pdf=render |
Similar Items
-
Integrating transcriptomics with metabolic modeling predicts biomarkers and drug targets for Alzheimer's disease.
by: Shiri Stempler, et al.
Published: (2014-01-01) -
Metabolic modeling predicts perturbations extending lifespan in yeast and counteracting aging in mammalian muscle
by: Yizhak Keren, et al.
Published: (2012-06-01) -
A Robust Optimization Approach to Backup Network Design With Random Failures
by: Johnston, Matthew Ryan, et al.
Published: (2018) -
A robust optimization approach to backup network design with random failures
by: Johnston, Matthew Ryan, et al.
Published: (2011) -
Data-Driven Metabolic Pathway Compositions Enhance Cancer Survival Prediction.
by: Noam Auslander, et al.
Published: (2016-09-01)