Glutathione S-transferase M1 and T1 genes deletion polymorphisms and blood pressure control among treated essential hypertensive patients in Burkina Faso

• Main Authors: Herman Karim Sombié, Daméhan Tchelougou, Abdoul Karim Ouattara, Jonas Koudougou Kologo, Pegdwendé Abel Sorgho, Dogfunianalo Somda, Sakinata Yaméogo, Arsène Wendpagnangdé Zongo, Isabelle Touwendpoulimdé Kiendrebeogo, Enagnon Tiémoko Herman Donald Adoko, Albert Théophane Yonli, Florencia Wendkuuni Djigma, Patrice Zabsonré, Hassanata Millogo, Jacques Simporé
• Format: Article
• Language: English
• Published: BMC 2021-06-01
• Series: BMC Research Notes
• Subjects: Blood pressure control; Essential hypertension; GSTM1; GSTT1; Burkina Faso
• Online Access: https://doi.org/10.1186/s13104-021-05658-w
• ISSN: 1756-0500

Abstract Objective Glutathione S-transferases have been associated with experimental resistance to some drugs. The present study investigated the factors associated with blood pressure control in patients with essential hypertension, especially the role of GSTT1 and GSTM1 genes polymorphisms. This cross-sectional study in Burkina Faso consisted of 200 patients with essential hypertension and under treatment. Results In the present study, 57.5% (115/200) of patients had their hypertension under control. No statistically significant difference was found between controlled and uncontrolled groups for anthropometric and biochemical parameters as well as for GSTT1 or GSTM1 gene polymorphisms (all p > 0.05). Current alcohol consumption (OR = 3.04; CI 1.88–6.13; p < 0.001), Physical inactivity (OR = 3.07; CI 1.71–5.49; p < 0.001), severe hypertension before any treatment (Grade III [OR = 3.79; CI 2.00–7.17; p < 0.001]) and heart damage (OR = 3, 14; CI 1.59–6.02; p < 0.001) were statistically more frequent in uncontrolled essential hypertensive patients than controlled hypertensive patients.