Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma
Abstract Background and purpose To evaluate the effect of timing of radiotherapy (RT) on survival in patients with newly diagnosed primary glioblastoma (GBM) treated with the same therapeutical protocol. Materials and methods Patients with newly diagnosed primary GBM treated with the same therapeuti...
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doaj-91456d88e08440438a5536541f01b2102020-11-25T02:02:36ZengBMCRadiation Oncology1748-717X2019-04-0114111010.1186/s13014-019-1272-6Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastomaSotirios Katsigiannis0Boris Krischek1Stefanie Barleanu2Stefan Grau3Norbert Galldiks4Marco Timmer5Christoph Kabbasch6Roland Goldbrunner7Pantelis Stavrinou8Department of Neurosurgery, University Hospital of BochumDepartment of Neurosurgery, University Hospital CologneDepartment of Neurosurgery, University Hospital CologneDepartment of Neurosurgery, University Hospital CologneDepartment of Neurology, University Hospital CologneDepartment of Neurosurgery, University Hospital CologneDepartment of Neuroradiology, University Hospital CologneDepartment of Neurosurgery, University Hospital CologneDepartment of Neurosurgery, University Hospital CologneAbstract Background and purpose To evaluate the effect of timing of radiotherapy (RT) on survival in patients with newly diagnosed primary glioblastoma (GBM) treated with the same therapeutical protocol. Materials and methods Patients with newly diagnosed primary GBM treated with the same therapeutical scheme between 2010 and 2015 in our institution were retrospectively reviewed. The population was trichotomized based on the time interval from surgery till initiation of RT (< 28 days, 28–33 days, > 33 days). Kaplan-Meier and Cox regression analyses were used to compare progression free survival (PFS) and overall survival (OS) between the groups. The influence of various extensively studied prognostic factors on survival was assessed by multivariate analysis. Results One-hundred-fifty-one patients met the inclusion criteria. Between the three groups no significant difference in PFS (p = 0.516) or OS (p = 0.902) could be demonstrated. Residual tumor volume (RTV) and midline structures involvement were identified as independent prognostic factors of PFS while age, O-6-Methylguanine Methyltransferase (MGMT) status, Ki67 index, RTV and midline structures involvement represented independent predictors of OS. Patients starting RT after a prolonged delay (> 48 days) exhibited a significantly shorter OS (p = 0.034). Conclusion Initiation of RT within a timeframe of 48 days is not associated with worsened survival. A prolonged delay (> 48 days) may be associated with worse OS. RT should neither be delayed, nor forced, but should rather start timely, as soon as the patient has recovered from surgery.http://link.springer.com/article/10.1186/s13014-019-1272-6GlioblastomaTiming of radiotherapyPrognostic factorsSurvivalProgression free survival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sotirios Katsigiannis Boris Krischek Stefanie Barleanu Stefan Grau Norbert Galldiks Marco Timmer Christoph Kabbasch Roland Goldbrunner Pantelis Stavrinou |
spellingShingle |
Sotirios Katsigiannis Boris Krischek Stefanie Barleanu Stefan Grau Norbert Galldiks Marco Timmer Christoph Kabbasch Roland Goldbrunner Pantelis Stavrinou Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma Radiation Oncology Glioblastoma Timing of radiotherapy Prognostic factors Survival Progression free survival |
author_facet |
Sotirios Katsigiannis Boris Krischek Stefanie Barleanu Stefan Grau Norbert Galldiks Marco Timmer Christoph Kabbasch Roland Goldbrunner Pantelis Stavrinou |
author_sort |
Sotirios Katsigiannis |
title |
Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma |
title_short |
Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma |
title_full |
Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma |
title_fullStr |
Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma |
title_full_unstemmed |
Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma |
title_sort |
impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma |
publisher |
BMC |
series |
Radiation Oncology |
issn |
1748-717X |
publishDate |
2019-04-01 |
description |
Abstract Background and purpose To evaluate the effect of timing of radiotherapy (RT) on survival in patients with newly diagnosed primary glioblastoma (GBM) treated with the same therapeutical protocol. Materials and methods Patients with newly diagnosed primary GBM treated with the same therapeutical scheme between 2010 and 2015 in our institution were retrospectively reviewed. The population was trichotomized based on the time interval from surgery till initiation of RT (< 28 days, 28–33 days, > 33 days). Kaplan-Meier and Cox regression analyses were used to compare progression free survival (PFS) and overall survival (OS) between the groups. The influence of various extensively studied prognostic factors on survival was assessed by multivariate analysis. Results One-hundred-fifty-one patients met the inclusion criteria. Between the three groups no significant difference in PFS (p = 0.516) or OS (p = 0.902) could be demonstrated. Residual tumor volume (RTV) and midline structures involvement were identified as independent prognostic factors of PFS while age, O-6-Methylguanine Methyltransferase (MGMT) status, Ki67 index, RTV and midline structures involvement represented independent predictors of OS. Patients starting RT after a prolonged delay (> 48 days) exhibited a significantly shorter OS (p = 0.034). Conclusion Initiation of RT within a timeframe of 48 days is not associated with worsened survival. A prolonged delay (> 48 days) may be associated with worse OS. RT should neither be delayed, nor forced, but should rather start timely, as soon as the patient has recovered from surgery. |
topic |
Glioblastoma Timing of radiotherapy Prognostic factors Survival Progression free survival |
url |
http://link.springer.com/article/10.1186/s13014-019-1272-6 |
work_keys_str_mv |
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