Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders
Among the various mechanisms involved in aging, it was proposed long ago that a prominent role is played by oxidative stress. A major way by which the latter can provoke structural damage to biological macromolecules, such as DNA, lipids, and proteins, is by fueling the peroxidation of membrane lipi...
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doaj-9148a826367c48b59ad1fa3aa7f876822020-11-25T02:21:04ZengMDPI AGAntioxidants2076-39212018-07-017810210.3390/antiox7080102antiox7080102Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related DisordersGiuseppina Barrera0Stefania Pizzimenti1Martina Daga2Chiara Dianzani3Alessia Arcaro4Giovanni Paolo Cetrangolo5Giulio Giordano6Marie Angele Cucci7Maria Graf8Fabrizio Gentile9Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, 10124 Turin, ItalyDipartimento di Scienze Cliniche e Biologiche, Università di Torino, 10124 Turin, ItalyDipartimento di Scienze Cliniche e Biologiche, Università di Torino, 10124 Turin, ItalyDipartimento di Scienze e Tecnologia del Farmaco, Università di Torino, 10124 Turin, ItalyDipartimento di Medicina e Scienze della Salute “V. Tiberio”, Università del Molise, 86100 Campobasso, ItalyDipartimento di Medicina e Scienze della Salute “V. Tiberio”, Università del Molise, 86100 Campobasso, ItalyPresidio Ospedaliero “A. Cardarelli”, Azienda Sanitaria Regione Molise, 86100 Campobasso, ItalyDipartimento di Scienze Cliniche e Biologiche, Università di Torino, 10124 Turin, ItalyPresidio Ospedaliero “A. Cardarelli”, Azienda Sanitaria Regione Molise, 86100 Campobasso, ItalyDipartimento di Medicina e Scienze della Salute “V. Tiberio”, Università del Molise, 86100 Campobasso, ItalyAmong the various mechanisms involved in aging, it was proposed long ago that a prominent role is played by oxidative stress. A major way by which the latter can provoke structural damage to biological macromolecules, such as DNA, lipids, and proteins, is by fueling the peroxidation of membrane lipids, leading to the production of several reactive aldehydes. Lipid peroxidation-derived aldehydes can not only modify biological macromolecules, by forming covalent electrophilic addition products with them, but also act as second messengers of oxidative stress, having relatively extended lifespans. Their effects might be further enhanced with aging, as their concentrations in cells and biological fluids increase with age. Since the involvement and the role of lipid peroxidation-derived aldehydes, particularly of 4-hydroxynonenal (HNE), in neurodegenerations, inflammation, and cancer, has been discussed in several excellent recent reviews, in the present one we focus on the involvement of reactive aldehydes in other age-related disorders: osteopenia, sarcopenia, immunosenescence and myelodysplastic syndromes. In these aging-related disorders, characterized by increases of oxidative stress, both HNE and malondialdehyde (MDA) play important pathogenic roles. These aldehydes, and HNE in particular, can form adducts with circulating or cellular proteins of critical functional importance, such as the proteins involved in apoptosis in muscle cells, thus leading to their functional decay and acceleration of their molecular turnover and functionality. We suggest that a major fraction of the toxic effects observed in age-related disorders could depend on the formation of aldehyde-protein adducts. New redox proteomic approaches, pinpointing the modifications of distinct cell proteins by the aldehydes generated in the course of oxidative stress, should be extended to these age-associated disorders, to pave the way to targeted therapeutic strategies, aiming to alleviate the burden of morbidity and mortality associated with these disturbances.http://www.mdpi.com/2076-3921/7/8/102aldehydesosteopeniasarcopeniamyelodysplastic syndromesimmunosenescence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giuseppina Barrera Stefania Pizzimenti Martina Daga Chiara Dianzani Alessia Arcaro Giovanni Paolo Cetrangolo Giulio Giordano Marie Angele Cucci Maria Graf Fabrizio Gentile |
spellingShingle |
Giuseppina Barrera Stefania Pizzimenti Martina Daga Chiara Dianzani Alessia Arcaro Giovanni Paolo Cetrangolo Giulio Giordano Marie Angele Cucci Maria Graf Fabrizio Gentile Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders Antioxidants aldehydes osteopenia sarcopenia myelodysplastic syndromes immunosenescence |
author_facet |
Giuseppina Barrera Stefania Pizzimenti Martina Daga Chiara Dianzani Alessia Arcaro Giovanni Paolo Cetrangolo Giulio Giordano Marie Angele Cucci Maria Graf Fabrizio Gentile |
author_sort |
Giuseppina Barrera |
title |
Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders |
title_short |
Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders |
title_full |
Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders |
title_fullStr |
Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders |
title_full_unstemmed |
Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders |
title_sort |
lipid peroxidation-derived aldehydes, 4-hydroxynonenal and malondialdehyde in aging-related disorders |
publisher |
MDPI AG |
series |
Antioxidants |
issn |
2076-3921 |
publishDate |
2018-07-01 |
description |
Among the various mechanisms involved in aging, it was proposed long ago that a prominent role is played by oxidative stress. A major way by which the latter can provoke structural damage to biological macromolecules, such as DNA, lipids, and proteins, is by fueling the peroxidation of membrane lipids, leading to the production of several reactive aldehydes. Lipid peroxidation-derived aldehydes can not only modify biological macromolecules, by forming covalent electrophilic addition products with them, but also act as second messengers of oxidative stress, having relatively extended lifespans. Their effects might be further enhanced with aging, as their concentrations in cells and biological fluids increase with age. Since the involvement and the role of lipid peroxidation-derived aldehydes, particularly of 4-hydroxynonenal (HNE), in neurodegenerations, inflammation, and cancer, has been discussed in several excellent recent reviews, in the present one we focus on the involvement of reactive aldehydes in other age-related disorders: osteopenia, sarcopenia, immunosenescence and myelodysplastic syndromes. In these aging-related disorders, characterized by increases of oxidative stress, both HNE and malondialdehyde (MDA) play important pathogenic roles. These aldehydes, and HNE in particular, can form adducts with circulating or cellular proteins of critical functional importance, such as the proteins involved in apoptosis in muscle cells, thus leading to their functional decay and acceleration of their molecular turnover and functionality. We suggest that a major fraction of the toxic effects observed in age-related disorders could depend on the formation of aldehyde-protein adducts. New redox proteomic approaches, pinpointing the modifications of distinct cell proteins by the aldehydes generated in the course of oxidative stress, should be extended to these age-associated disorders, to pave the way to targeted therapeutic strategies, aiming to alleviate the burden of morbidity and mortality associated with these disturbances. |
topic |
aldehydes osteopenia sarcopenia myelodysplastic syndromes immunosenescence |
url |
http://www.mdpi.com/2076-3921/7/8/102 |
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