| Summary: | A growing number of studies have demonstrated the role of quantitative
electroencephalography in assessing brain function in neuro-intensive care
units. Still, few studies have examined patients with large hemisphere infarction. Thirty patients with large hemisphere infarction were included
in this preliminary study, and the patients were divided into the death group (twelve
patients) and survival group (eighteen patients). Electroencephalography monitored the patients, and
a computerized tomography inspection was performed. The quantitative electroencephalography of
the alpha-beta/delta-theta ratio change index was calculated and used to
predict the prognosis of early large hemisphere infarction patients. The relationship between three months
modified Rankin Scale, and alpha-beta/delta-theta ratio change
index was analyzed. The death group had negative changes for alpha-beta/delta-theta ratio
change index (-0.0140 ± 0.0193), while there was an opposite trend in the
survival group, the median is 0.004 (-0.0067, 0.0137). The death group’s brain
function decreased more severely and rapidly than the survival group (P
= 0.004). The highest diagnostic value (AUC value 0.815, P < 0.001)
was observed when the alpha-beta/delta-theta ratio change index dropped and exceeded -0.008. The area
under the GCS curve was 0.674, but its predictive ability was low (P =
0.094). The correlation analysis result showed that the 3-month modified Rankin Scale was
negatively correlated with the alpha-beta/delta-theta ratio change index (r = -0.489, P =
0.006). The alpha-beta/delta-theta ratio change index is considered an indicator for predicting the prognosis of large hemisphere infarction. Therefore, the alpha-beta/delta-theta ratio change index may be a reliable quantitative EEG parameter that predicts the early prognosis of patients with acute large hemispheric infarction.
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