Chronic stress induces formation of stress granules and pathological TDP-43 aggregates in human ALS fibroblasts and iPSC-motoneurons

Chronic stress induces formation of stress granules and pathological TDP-43 aggregates in human ALS fibroblasts and iPSC-motoneurons

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative diseases characterized by the presence of neuropathological aggregates of phosphorylated TDP-43 (P-TDP-43) protein. The RNA-binding protein TDP-43 participates also to cell stress response by forming st...

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Bibliographic Details
Main Authors: Antonia Ratti, Valentina Gumina, Paola Lenzi, Patrizia Bossolasco, Federica Fulceri, Clara Volpe, Donatella Bardelli, Francesca Pregnolato, AnnaMaria Maraschi, Francesco Fornai, Vincenzo Silani, Claudia Colombrita
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Neurobiology of Disease
Subjects:
Stress granules
Chronic stress
ALS
TDP-43
Pathological aggregates
Fibroblast
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303260

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