Static versus dynamic intensity-modulated radiotherapy: Profile of integral dose in carcinoma of the nasopharynx
This study is aimed to evaluate the impact of static and dynamic intensity modulated radiotherapy (IMRT) delivery techniques planned with Eclipse TPS on the integral dose to the healthy normal tissue surrounding the tumor-bearing area and to the volume receiving doses < 5 Gy in patients with...
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Wolters Kluwer Medknow Publications
2009-01-01
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doaj-9165c65e48b648aea17ad13e39837e4b2020-11-24T23:41:29ZengWolters Kluwer Medknow PublicationsJournal of Medical Physics0971-62031998-39132009-01-013426672Static versus dynamic intensity-modulated radiotherapy: Profile of integral dose in carcinoma of the nasopharynxJothybasu KBahl AmitSubramani VRath GSharma DJulka PThis study is aimed to evaluate the impact of static and dynamic intensity modulated radiotherapy (IMRT) delivery techniques planned with Eclipse TPS on the integral dose to the healthy normal tissue surrounding the tumor-bearing area and to the volume receiving doses < 5 Gy in patients with carcinoma nasopharynx treated with Simultaneous Integrated Boost IMRT (SIB-IMRT). Ten patients with carcinoma nasopharynx were chosen for this dosimetric study. IMRT plans were generated with 6X using dynamic multileaf collimator (DMLC) and static multileaf collimator (SMLC) with 5, 10 and 15 intensity levels (L). Integral dose, volume receiving 5 Gy, number of monitor units (MU) is compared against DMLC. The mean difference in the MU delivered per fraction between 5, 10 and 15 L SMLC and DMLC was -13.25% (<i> P</i> < 0.001, with paired t test), -11.82% (<i> P</i> < 0.001) and -10.81% (<i> P</i> < 0.001), respectively. The mean difference in the integral dose with 5, 10 and 15 L compared to DMLC was -2.96% (<i> P</i> < 0.001), -2.67% (<i> P</i> = 0.016) and -0.39% (<i> P</i> = 0.430), respectively. However, the difference in low-dose volume (V5Gy) was statistically insignificant with mean difference of 0.60% (<i> P</i> = 0.23), 1.18% (<i> P</i> = 0.017) and 1.70% (<i> P</i> = 0.078), respectively for 5, 10 and 15 L compared to DMLC. Our results show that while choosing the IMRT delivery technique using conventional MLC the concerns about integral dose and volume receiving very low doses such as 5 Gy can be ignored.http://www.jmp.org.in/article.asp?issn=0971-6203;year=2009;volume=34;issue=2;spage=66;epage=72;aulast=JothybasuDynamic multileaf collimatorintegral doseintensity-modulated radiotherapystatic multileaf collimator |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jothybasu K Bahl Amit Subramani V Rath G Sharma D Julka P |
spellingShingle |
Jothybasu K Bahl Amit Subramani V Rath G Sharma D Julka P Static versus dynamic intensity-modulated radiotherapy: Profile of integral dose in carcinoma of the nasopharynx Journal of Medical Physics Dynamic multileaf collimator integral dose intensity-modulated radiotherapy static multileaf collimator |
author_facet |
Jothybasu K Bahl Amit Subramani V Rath G Sharma D Julka P |
author_sort |
Jothybasu K |
title |
Static versus dynamic intensity-modulated radiotherapy: Profile of integral dose in carcinoma of the nasopharynx |
title_short |
Static versus dynamic intensity-modulated radiotherapy: Profile of integral dose in carcinoma of the nasopharynx |
title_full |
Static versus dynamic intensity-modulated radiotherapy: Profile of integral dose in carcinoma of the nasopharynx |
title_fullStr |
Static versus dynamic intensity-modulated radiotherapy: Profile of integral dose in carcinoma of the nasopharynx |
title_full_unstemmed |
Static versus dynamic intensity-modulated radiotherapy: Profile of integral dose in carcinoma of the nasopharynx |
title_sort |
static versus dynamic intensity-modulated radiotherapy: profile of integral dose in carcinoma of the nasopharynx |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Medical Physics |
issn |
0971-6203 1998-3913 |
publishDate |
2009-01-01 |
description |
This study is aimed to evaluate the impact of static and dynamic intensity modulated radiotherapy (IMRT) delivery techniques planned with Eclipse TPS on the integral dose to the healthy normal tissue surrounding the tumor-bearing area and to the volume receiving doses < 5 Gy in patients with carcinoma nasopharynx treated with Simultaneous Integrated Boost IMRT (SIB-IMRT). Ten patients with carcinoma nasopharynx were chosen for this dosimetric study. IMRT plans were generated with 6X using dynamic multileaf collimator (DMLC) and static multileaf collimator (SMLC) with 5, 10 and 15 intensity levels (L). Integral dose, volume receiving 5 Gy, number of monitor units (MU) is compared against DMLC. The mean difference in the MU delivered per fraction between 5, 10 and 15 L SMLC and DMLC was -13.25% (<i> P</i> < 0.001, with paired t test), -11.82% (<i> P</i> < 0.001) and -10.81% (<i> P</i> < 0.001), respectively. The mean difference in the integral dose with 5, 10 and 15 L compared to DMLC was -2.96% (<i> P</i> < 0.001), -2.67% (<i> P</i> = 0.016) and -0.39% (<i> P</i> = 0.430), respectively. However, the difference in low-dose volume (V5Gy) was statistically insignificant with mean difference of 0.60% (<i> P</i> = 0.23), 1.18% (<i> P</i> = 0.017) and 1.70% (<i> P</i> = 0.078), respectively for 5, 10 and 15 L compared to DMLC. Our results show that while choosing the IMRT delivery technique using conventional MLC the concerns about integral dose and volume receiving very low doses such as 5 Gy can be ignored. |
topic |
Dynamic multileaf collimator integral dose intensity-modulated radiotherapy static multileaf collimator |
url |
http://www.jmp.org.in/article.asp?issn=0971-6203;year=2009;volume=34;issue=2;spage=66;epage=72;aulast=Jothybasu |
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