Rift Valley Fever: Important Considerations for Risk Mitigation and Future Outbreaks
Rift Valley fever virus (RVFV) is a zoonotic phlebovirus of the <i>Phenuiviridae</i> family with great opportunity for emergence in previously unaffected regions, despite its current geographical limits. Outbreaks of RVFV often infect humans or domesticated animals, such as livestock, co...
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doaj-916c16842ad04a2a8efd2fd2c9d2154c2020-11-25T03:07:19ZengMDPI AGTropical Medicine and Infectious Disease2414-63662020-06-015898910.3390/tropicalmed5020089Rift Valley Fever: Important Considerations for Risk Mitigation and Future OutbreaksElysse N. Grossi-Soyster0A. Desiree LaBeaud1Department of Pediatrics, Division of Infectious Disease, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Pediatrics, Division of Infectious Disease, Stanford University School of Medicine, Stanford, CA 94305, USARift Valley fever virus (RVFV) is a zoonotic phlebovirus of the <i>Phenuiviridae</i> family with great opportunity for emergence in previously unaffected regions, despite its current geographical limits. Outbreaks of RVFV often infect humans or domesticated animals, such as livestock, concurrently and occur sporadically, ranging from localized outbreaks in villages to multi-country events that spread rapidly. The true burden of Rift Valley fever (RVF) is not well defined due to underreporting, misdiagnosis caused by the broad spectrum of disease presentation, and minimal access for rapid and accurate laboratory confirmation. Severe symptoms may include hemorrhagic fever, loss of vision, psychological impairment or disturbances, and organ failure. Those living in endemic areas and travelers should be aware of the potential for exposure to ongoing outbreaks or interepidemic transmission, and engage in behaviors to minimize exposure risks, as vaccinations in humans are currently unavailable and animal vaccinations are not used routinely or ubiquitously. The lack of vaccines approved for use in humans is concerning, as RVFV has proven to be highly pathogenic in naïve populations, causing severe disease in a large percent of confirmed cases, which could have considerable impact on human health.https://www.mdpi.com/2414-6366/5/2/89Rift Valley fever (RVF)arbovirusesmosquito-borne viruseszoonosesOne Healthtravel medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elysse N. Grossi-Soyster A. Desiree LaBeaud |
spellingShingle |
Elysse N. Grossi-Soyster A. Desiree LaBeaud Rift Valley Fever: Important Considerations for Risk Mitigation and Future Outbreaks Tropical Medicine and Infectious Disease Rift Valley fever (RVF) arboviruses mosquito-borne viruses zoonoses One Health travel medicine |
author_facet |
Elysse N. Grossi-Soyster A. Desiree LaBeaud |
author_sort |
Elysse N. Grossi-Soyster |
title |
Rift Valley Fever: Important Considerations for Risk Mitigation and Future Outbreaks |
title_short |
Rift Valley Fever: Important Considerations for Risk Mitigation and Future Outbreaks |
title_full |
Rift Valley Fever: Important Considerations for Risk Mitigation and Future Outbreaks |
title_fullStr |
Rift Valley Fever: Important Considerations for Risk Mitigation and Future Outbreaks |
title_full_unstemmed |
Rift Valley Fever: Important Considerations for Risk Mitigation and Future Outbreaks |
title_sort |
rift valley fever: important considerations for risk mitigation and future outbreaks |
publisher |
MDPI AG |
series |
Tropical Medicine and Infectious Disease |
issn |
2414-6366 |
publishDate |
2020-06-01 |
description |
Rift Valley fever virus (RVFV) is a zoonotic phlebovirus of the <i>Phenuiviridae</i> family with great opportunity for emergence in previously unaffected regions, despite its current geographical limits. Outbreaks of RVFV often infect humans or domesticated animals, such as livestock, concurrently and occur sporadically, ranging from localized outbreaks in villages to multi-country events that spread rapidly. The true burden of Rift Valley fever (RVF) is not well defined due to underreporting, misdiagnosis caused by the broad spectrum of disease presentation, and minimal access for rapid and accurate laboratory confirmation. Severe symptoms may include hemorrhagic fever, loss of vision, psychological impairment or disturbances, and organ failure. Those living in endemic areas and travelers should be aware of the potential for exposure to ongoing outbreaks or interepidemic transmission, and engage in behaviors to minimize exposure risks, as vaccinations in humans are currently unavailable and animal vaccinations are not used routinely or ubiquitously. The lack of vaccines approved for use in humans is concerning, as RVFV has proven to be highly pathogenic in naïve populations, causing severe disease in a large percent of confirmed cases, which could have considerable impact on human health. |
topic |
Rift Valley fever (RVF) arboviruses mosquito-borne viruses zoonoses One Health travel medicine |
url |
https://www.mdpi.com/2414-6366/5/2/89 |
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